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RESEARCH PRODUCT
Electroencephalography as a Non-Invasive Biomarker of Alzheimer’s Disease: A Forgotten Candidate to Substitute CSF Molecules?
Begoña LopezAna LloretJose-luis LeonMaria-angeles LloretDaniel EsteveAna Cervera-ferriPaloma Monllorsubject
non-invasive biomarkerscerebral rhythmsQH301-705.5ReviewDiseaseElectroencephalographyBioinformaticsCatalysisInorganic ChemistryAlzheimer DiseaseAlzheimer’s disease diagnosismedicineAnimalsHumansEEGBiology (General)Physical and Theoretical ChemistryQD1-999Molecular BiologySpectroscopyCerebrospinal Fluidmedicine.diagnostic_testbusiness.industryOrganic ChemistryNon invasive biomarkerssynchronyElectroencephalographyGeneral MedicineComputer Science ApplicationsClinical PracticeChemistrycomplexitybusinessBiomarkersalpha wavedescription
Biomarkers for disease diagnosis and prognosis are crucial in clinical practice. They should be objective and quantifiable and respond to specific therapeutic interventions. Optimal biomarkers should reflect the underlying process (pathological or not), be reproducible, widely available, and allow measurements repeatedly over time. Ideally, biomarkers should also be non-invasive and cost-effective. This review aims to focus on the usefulness and limitations of electroencephalography (EEG) in the search for Alzheimer’s disease (AD) biomarkers. The main aim of this article is to review the evolution of the most used biomarkers in AD and the need for new peripheral and, ideally, non-invasive biomarkers. The characteristics of the EEG as a possible source for biomarkers will be revised, highlighting its advantages compared to the molecular markers available so far.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-10-01 | International Journal of Molecular Sciences |