6533b82bfe1ef96bd128e256
RESEARCH PRODUCT
Pterostilbene: Biomedical applications
Angel OrtegaJosé M. EstrelaMaria L. RodriguezMiguel AsensiSalvador Menasubject
Biomedical ResearchCancer preventionPterostilbenePlant Extractsbusiness.industryBiochemistry (medical)Clinical BiochemistryInsulin sensitivityAntineoplastic AgentsCardiovascular AgentsResveratrolPharmacologyProtective AgentsGeneral Biochemistry Genetics and Molecular BiologyCell Linechemistry.chemical_compoundchemistryStilbenesAnimalsHumansMedicinebusinessdescription
Resveratrol and its naturally dimethylated analog, pterostilbene, show similar biological activities. However, the higher in vivo bioavailability of pterostilbene represents a fundamental advantage. The main focus of this review is on biomedical applications of pterostilbene. The metabolism and pharmacokinetics of this stilbene in inflammatory dermatoses and photoprotection, cancer prevention and therapy, insulin sensitivity, blood glycemia and lipid levels, cardiovascular diseases, aging, and memory and cognition are addressed. Safety and toxicity, as well as recommendations for future research and biomedical uses, are discussed. This review includes comparisons between pterostilbene and other polyphenols, with particular emphasis on resveratrol. Potential benefits of using combinations of different polyphenols are considered. Based on present evidences we conclude that pterostilbene is an active phytonutrient and also a potential drug with multiple biomedical applications.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-07-02 | Critical Reviews in Clinical Laboratory Sciences |