6533b82cfe1ef96bd128e91b

RESEARCH PRODUCT

Four channels multi-illumination single-holographic-exposure lensless Fresnel (MISHELF) microscopy

José ÁNgel Picazo-buenoLuis GraneroMartín SanzJavier GarciaVicente Micó

subject

PhysicsMicroscopebusiness.industryMechanical EngineeringNoise reductionHolography02 engineering and technology021001 nanoscience & nanotechnology01 natural sciencesMultiplexingNoise (electronics)Atomic and Molecular Physics and OpticsElectronic Optical and Magnetic Materialslaw.invention010309 opticsOpticslaw0103 physical sciencesDigital image processingMicroscopyElectrical and Electronic Engineering0210 nano-technologyPhase retrievalbusiness

description

Abstract MISHELF microscopy [Opt. Express 23, 21352 (2015)] has been recently reported as the background technology of a new concept of compact, cost-effective and field-portable lensless microscope [Sci. Rep. 7, 43291 (2017)] based on wavelength multiplexing and a fast and robust algorithm for twin image minimization and noise reduction. In this manuscript, MISHELF microscopy is expanded beyond its actual configuration by considering 4 illumination/detection channels while retaining its working principle concerning single-shot, twin image mitigation and noise averaging. Proof of principle validation of the proposed improvement is conducted through experiments with a resolution test target and a micro sphere sample.

https://doi.org/10.1016/j.optlaseng.2018.06.020