6533b82cfe1ef96bd128e967
RESEARCH PRODUCT
New type of chimeric fusion product between theEWS andATF1 genes in clear cell sarcoma (malignant melanoma of soft parts)
Concha López-ginésCarmen CardaCarlos MonteagudoAntonio Llombart-boschJ BoixAntonio Pellínsubject
GeneticsCancer ResearchATF1MelanomafungiBreakpointCancerBiologymedicine.diseaseIn vivoGeneticsmedicineCancer researchClear-cell sarcomaGenedescription
We report a new case of clear cell sarcoma (CCS) harboring the t(12;22)(q13;q12). Reverse transcription-polymerase chain reaction (RT-PCR) analysis revealed the presence of a chimeric transcript between the EWS and ATF1 genes, both in primary and metastatic tissue. Sequencing studies disclosed an in-frame fusion between EWS gene codon 265 and ATF1 gene codon 110. This breakpoint has not been reported previously and indicates an important in vivo loss of EWS and ATF1 gene domains, which could be associated with the unusually aggressive behavior of this tumor. Genes Chromosomes Cancer 23:358–360, 1998. © 1998 Wiley-Liss, Inc.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1998-12-01 | Genes, Chromosomes and Cancer |