Clinical presentation, disease course and outcome of COVID-19 in hospitalized patients with and without pre-existing cardiac disease

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RESEARCH PRODUCT

Clinical presentation, disease course and outcome of COVID-19 in hospitalized patients with and without pre-existing cardiac disease – a cohort study across eighteen countries

D A A M Schellings M Neufang G Captur G Captur J Schaap R S Hermanides C Riedel W L Bor S G Mazzilli J L Van Doorn J P Van Meerbeeck M F L Meijs J Trauth I. C. C. Van Der Horst E J Meijer A Friedrichs J Redon C A Biolé K Hellwig E Tessitore F J F Broeyer Bryan Williams Bryan Williams C Degenhardt M Caputo Gerry P Mccann A Moriarty Azfar Zaman R M M Gevers C E Delsing A G Er A J M Van Boxem E Lensink O V Blagova D F Mesitskaya R S Patel E Saneei A N Alnafie N Y Y Al-windy Marijke Linschoten M Von Bergwelt-baildon E Wierda K Jourdan Angela C. Shore M Tajdini S E Van Der Kooi R. Macias Ruiz S Grangeon A Guclu Abdullah M. Alshehri A G M Zondag T Veneman L Eberwein Chiara Bucciarelli-ducci Chiara Bucciarelli-ducci M Broekman M. Van Smeden K Wille R M A Van De Wal T E Alling P H M Westendorp A. Van Lingen R Pisters W R M Hermans A Aujayeb K Elshinawy M Milovanovic A.g. Raafs E Vlieghe I C D Westendorp L E Zijlstra Michiel T H M Henkens B Cosyns Robert M. Bell A J Moss J A Offerhaus K Van Aken A L Groenendijk I M J Drost M Worm C P M Van Nes R Strauss C Weytjens M J G T Vehreschild A Mosterd D Rauschning N C Lea J M Kwakkel-van Erp S Handgraaf M E Emans J. De Sutter H P A A Van Veen M G Perrelli N Knufman S Borgmann H Poorhosseini P Woudstra R J Thomson R Ahmed M Alshahrani J T Drost F Dormal L I Veldhuis D O Verschure F V Y Tjong Bas L.j.h. Kietselaer M J Forner M Bos A C Reidinga P Messiaen A M Willems H Bleijendaal D P Ripley J.k. De Vries J Rüddel J Seelig C Ball E P A Van Iperen S Rieg M W J Van Hessen N T B Scholte J B Ferreira F S Van Den Brink S E Jansen P Den Boer-penning G L Ten Kate B A S Koole S Dolff C Piepel C Spinner M Kochanek M Kochanek J. M. Ten Berg R Salah M Z H Kolk A Shafiee N Charlotte P Van Der Meer B Jensen J Schubert M Hower A F M Kuijper R A Tio L Kuipers-elferink L Montagna P M Van Der Zee D Heigener Lucia S.d. Jewbali N H Sturkenboom M Saxena R Byrom-goulthorp E A W De Bruijn J Nattermann N A Haenen A M Persoon M Bontje M Stecher Fahad Al-muhanna C M Kievit E Hellou S Reinders A Van Poppel Y A Almubarak J Lanznaster P Timmermans P Van Doorn Luis Romao K Hosseini F Hanses M Bianco C Römmele Stephane Heymans R L Anthonio F M A C Martens L Tometten J. Vom Dahl D J Van Der Heijden L Bosch P Dark C A Den Uil A J Melein A H Ruiter P R Nierop M Maarse N M Cardoso H Heidbuchel M Alkhalil W Guggemos S K Zoet-nugteren A Dunnink P Kleikers M M Rüthrich D Lomas L Pilgram J T Kielstein S Williams B C T Van Bussel A Pieterse-rots J Domange S Nadalin F M A Paris H A M Van Kesteren E A Badings C Anning E C E Bayraktar-verver J Huisman M Magro S Bruinsma E.m. Van Craenenbroeck U Merle F J Bermúdez Jiménes D H Van Dalen L Tercedor Sanchez M Van Der Graaf M M J M Van Der Linden N Isberner Folkert W. Asselbergs Folkert W. Asselbergs Amein K. Al-ali A. Van Der Sluis E A Van Beek S H Van Ierssel H G R Dorman R Zaal A M Wils Yigal M. Pinto I Lemoine B C Pölkerman V Van Marrewijk A Habib P C Smits B E Groenemeijer M J Reitsma E Mcfarlane R G Tieleman R G Tieleman M Hendriks-van Woerden J L Selder L Walter Alicia Uijl H J Siebelink I Voigt Gerard C.m. Linssen H Vial Mark T. Kearney D J Van De Watering H E Vonkeman J W M Van Eck B Grüner D G Gognieva P Markart K Hamilton C E E Van Ofwegen-hanekamp A Janssen C Raichle A I C Sousa W. H. Van Gilst B Hedayat L Gabriel S Stieglitz K W Wu P Vreugdenhil K Rothfuss M A C Koole T Westhoff S Prasad C M Van De Heyning A M H Koning T A C De Vries A M Al-rubaish A D Hilt E Parker E Dekimpe C E M Jakob C E M Jakob M I A Ribeiro B M Hessels-linnemeijer P S Monraats M J Van Kempen W Hermans-van Ast F J H Magdelijns K K Kui H E Haerkens-arends P Y Kopylov A Schut T C Jacobs P Van Der Harst

subject

medicine.medical_specialty Heart disease Coronavirus disease 2019 (COVID-19)business.industry Disease medicine.disease symbols.namesake Heart failure Internal medicine Relative risk medicine symbols Poisson regression Presentation (obstetrics)business Cohort study

description

AbstractAimsPatients with cardiac disease are considered high risk for poor outcomes following hospitalization with COVID-19. The primary aim of this study was to evaluate heterogeneity in associations between various heart disease subtypes and in-hospital mortality.Method and resultsWe used data from the CAPACITY-COVID registry and LEOSS study. Multivariable Poisson regression models were fitted to assess the association between different types of pre-existent heart disease and in-hospital mortality. 16,511 patients with COVID-19 were included (21.1% aged 66 – 75 years; 40.2% female) and 31.5% had a history of heart disease. Patients with heart disease were older, predominantly male and often had other comorbid conditions when compared to those without. Mortality was higher in patients with cardiac disease (29.7%; n=1545 versus 15.9%; n=1797). However, following multivariable adjustment this difference was not significant (adjusted risk ratio (aRR) 1.08 [95% CI 1.02 – 1.15; p-value 0.12 (corrected for multiple testing)]). Associations with in-hospital mortality by heart disease subtypes differed considerably, with the strongest association for heart failure aRR (1.19 [1.10 – 1.30]; p-value <0.018) particularly for severe NYHA III/IV) heart failure (aRR 1.41 [95% CI 1.20 – 1.64; p-value <0.018]. None of the other heart disease subtypes, including ischemic heart disease, remained significant after multivariable adjustment. Serious cardiac complications were diagnosed in <1% of patients.ConclusionConsiderable heterogeneity exists in the strength of association between heart disease subtypes and in-hospital mortality. Of all patients with heart disease, those with heart failure are at greatest risk of death when hospitalized with COVID-19. Serious cardiac complications are rare.

year	journal	country	edition	language
2021-03-12

https://doi.org/10.1101/2021.03.11.21253106