6533b82cfe1ef96bd128eaab
RESEARCH PRODUCT
Organocatalytic Enantioselective Synthesis of Pyrazoles Bearing a Quaternary Stereocenter
Fares Ibrahim AmrCarlos VilaM. Carmen MuñozGonzalo BlayJosé R. Pedrosubject
Isatin-derived ketimines010402 general chemistry01 natural sciencesBiochemistryCatalysisStereocenterchemistry.chemical_compoundCatàlisiCompostos orgànicsAsymmetric catalysisOrganic chemistryOrganocatalysis010405 organic chemistryChemistryEstereoquímicaOrganic ChemistryEnantioselective synthesisGeneral ChemistryQuaternary stereocenters0104 chemical sciencesThioureaFISICA APLICADAOrganocatalysisPyrazolesPyrazolonesQuímica orgànicadescription
An efficient one-pot asymmetric synthesis of pyrazoles bearing a chiral quaternary stereocenter has been developed. Quinine-derived thiourea catalyzed the enantioselective addition of pyrazolones to isatin-derived ketimines, providing the corresponding acetylated pyrazoles after in situ treatment with Ac2O/Et3N. The corresponding pyrazoles were afforded in high yields and excellent enantioselectivities.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-01-01 |