6533b82cfe1ef96bd128eaf4
RESEARCH PRODUCT
Mild, Fast, and Easy To Conduct MoCl5-Mediated Dehydrogenative Coupling Reactions in Flow
Timo MüllerPeter FranzmannIse UeckerSebastian B. BeilSiegfried R. Waldvogelsubject
010405 organic chemistryChemistryOrganic ChemistryMolybdenum pentachloride010402 general chemistry01 natural sciencesBiochemistryCombinatorial chemistryCoupling reaction0104 chemical sciencesFlow (mathematics)Yield (chemistry)Benzene derivativesOxidative coupling of methanePhysical and Theoretical Chemistrydescription
A convenient and straightforward approach to performing oxidative coupling reactions in flow is presented. A collection of electron-rich benzene derivatives was subjected to this protocol, and the distinct utility of molybdenum pentachloride (MoCl5) is established. Using this unexplored protocol, biphenyls could be obtained in 21–91% isolated yield. This simple protocol opens a new chapter in reagent-mediated dehydrogenative coupling reactions, and yields are compared to classical approaches.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-06-01 | Organic Letters |