6533b82cfe1ef96bd128eb68
RESEARCH PRODUCT
Immunohistochemical evaluation of bone marrow lymphoid nodules in chronic myeloproliferative disorders
G. CampesiVito FrancoAda Maria FlorenaF Aragonasubject
MalePolycythaemiaPathologymedicine.medical_specialtymedicine.drug_classMonoclonal antibodyPathology and Forensic MedicineBone Marrowhemic and lymphatic diseasesmedicineHumansLymphocytesMyelofibrosisMolecular BiologyAgedMyeloproliferative Disordersintegumentary systembiologybusiness.industryAntibodies MonoclonalCell BiologyGeneral MedicineMiddle Agedmedicine.diseaseImmunohistochemistryChronic myeloproliferative disordersmedicine.anatomical_structureChronic DiseaseMonoclonalbiology.proteinImmunohistochemistryFemaleBone marrowAntibodybusinessdescription
One hundred and seventy bone marrow biopsies from patients with chronic myeloproliferative disorders (CMPDs) were evaluated for the presence of lymphoid nodules (LNs) and were immunostained using a panel of monoclonal antibodies (UCHL1, 4KB5 and L26) recognizing different lymphocyte antigens. LNs were found in 35% of cases of idiopathic thrombocythaemia, 24.6% of myelofibrosis/osteomyelosclerosis, 18.2% of polycythaemia vera 12.1% of chronic myeloid leukaemia and 19.2% of borderline cases. Varying degrees of immunohistochemical positivity for the three antibodies tested were found. LNs were always made up of variable proportions of both T- and B-lymphocytes with a prevalence of T-cells. This latter observation suggests that bone marrow LNs in CMPDs could be an expression of reactivity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1991-07-01 | Virchows Archiv A Pathological Anatomy and Histopathology |