6533b82cfe1ef96bd128eb7f
RESEARCH PRODUCT
Synthesis and pharmacological study of ethyl 1-methyl-5-(substituted 3,4-dihydro-4-oxoquinazolin-3-yl)-1H-pyrazole-4-acetates
Nunzio Guido ManganoGiuseppe DaidoneVincenza Maria Catena CutuliLuca MantioneAntonina CarusoBenedetta MaggioDemetrio RaffaSalvatore Plesciasubject
MaleMagnetic Resonance SpectroscopySpectrophotometry InfraredStereochemistryAnalgesicAnti-Inflammatory AgentsPeritonitisPyrazoleChemical synthesisLethal Dose 50Rats Sprague-DawleyMicechemistry.chemical_compoundDrug DiscoveryBenzoquinonesAnimalsEdemaMoietyStomach UlcerQuinazolinonePharmacologyAnalgesicsBicyclic moleculeOrganic ChemistryGeneral MedicineAcute toxicityRatschemistryQuinazolinesLactamPyrazolesdescription
Several new ethyl 1-methyl-5-(substituted 3,4-dihydro-4-oxoquinazolin-3-yl)-1H-pyrazole-4-acetates 2, substituted at 2 and, alternatively at, 6, 7 or 8 positions of the quinazolinone nucleus, were synthesised. The compounds were screened for their analgesic and antiinflammatory activities, acute toxicity and ulcerogenic effect. Substitution in the benzene moiety of the quinazolinone ring did not show any advantage for the analgesic activity, whereas it improved in some cases the antiinflammatory activity. Some compounds showed appreciable antiinflammatory activity and, at the same time, very low ulcerogenic index.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2001-09-01 | European Journal of Medicinal Chemistry |