6533b82cfe1ef96bd128eba7

RESEARCH PRODUCT

Endothelin action on goat cerebral arteries.

Salvador LluchMaría RodríguezM C MartinezA. IrurzunJosé María VilaE. Martin De Aguilera

subject

medicine.medical_specialtymedicine.drug_classCerebral arteriesNicardipinePharmaceutical Sciencechemistry.chemical_elementStimulationCalcium channel blockerBiologyCalciumIn Vitro TechniquesMuscle Smooth VascularNicardipineInternal medicinemedicineAnimalsPharmacologyVoltage-dependent calcium channelEndothelinsGoatsCerebral ArteriesEndocrinologymedicine.anatomical_structurechemistrycardiovascular systemCalciumFemaleEndothelium VascularEndothelin receptormedicine.drugBlood vesselMuscle Contraction

description

Abstract Cumulative application of endothelin-1 (human) markedly constricted goat isolated cerebral arteries in a concentration-dependent manner. Contractile responses were not affected by removal of endothelial cells. Removal of extracellular calcium or addition of the calcium channel blocker nicardipine (10−7 M) failed to abolish responses to endothelin. The results suggest that the endothelium-independent constriction of cerebral arteries produced by endothelin cannot be explained solely by voltage-dependent calcium channels. The contractile responses are likely to be mediated by stimulation of specific receptors for this peptide.

yearjournalcountryeditionlanguage
1990-05-01The Journal of pharmacy and pharmacology
10.1111/j.2042-7158.1990.tb05433.xhttps://pubmed.ncbi.nlm.nih.gov/1976792