6533b82cfe1ef96bd128eba8
RESEARCH PRODUCT
Pain-evoked blink reflex
Burkhart BrommHanns Christian HopfJens Ellrichsubject
AdultMalePain ThresholdChinHot TemperatureInfrared RaysPhysiologyPainStimulationReflex responseCellular and Molecular NeuroscienceReference ValuesPhysiology (medical)Reaction TimeHumansMedicineNervous System Physiological PhenomenaCorneal reflexSkinBlinkingbusiness.industryLasersNociceptorsSupraorbital nerveMental nerveElectric StimulationLipNociceptionNociceptorFemaleNeurology (clinical)businessOrbitNeurosciencedescription
The electrically evoked blink reflex (BR) consists of an ipsilateral R1 component (R1) at 11 ms and two bilateral components R2 at 33 ms and R3 at 83 ms. It is still unclear whether the R2 is mediated by activation of tactile or nociceptive afferents. For testing the nociceptive hypothesis, nociceptors of the supraorbital nerve were selectively activated by infrared laser stimuli in 10 subjects. Only painful laser stimuli evoked a bilateral early polyphasic BR response (LR2) at 71 ms. Stimulation of infraorbital and mental nerve dermatomes was equally effective. A late bilateral reflex response at 130 ms was occasionally observed. Regarding the nociceptor activation time of about 40 ms, onset latencies were within the range of the electrically evoked R2 and R3, respectively. The good accordance of R2 and LR2 may be due to activation of identical nociceptive fibers or to convergence of electrically evoked tactile and laser-elicited nociceptive input onto common multireceptive neurons.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1997-03-01 | Muscle & Nerve |