6533b82cfe1ef96bd128ec7e
RESEARCH PRODUCT
A comparison of the transcriptome of Drosophila melanogaster in response to entomopathogenic fungus, ionizing radiation, starvation and cold shock
Lyubov ShilovaDmitry BorisoglebskyAlexey MoskalevEugenia DobrovolskayaMikhail V. ShaposhnikovMikhail V. ShaposhnikovAnton DanilovGeorge S. KrasnovIlya SolovevAnna V. KudryavtsevaAnna V. KudryavtsevaDarya PeregudovaEkaterina ProshkinaEkaterina ProshkinaNadezhda ZemskayaIrina SharapovaSvetlana ZhikrivetskayaSvetlana ZhikrivetskayaA V Snezhkinasubject
Ionizing radiationSurvivalTranscriptomeRadiation IonizingCellular stress responseGene expressionGeneticsmedicineAnimalsOrganismGeneticsCold shockLifespanbiologyResearchCold-Shock ResponseEntomopathogenic fungusFungibiology.organism_classificationCold shock responseCell biologyDrosophila melanogasterStarvationShock (circulatory)Entomopathogenic fungusGene expressionDrosophila melanogastermedicine.symptomTranscriptomeBiotechnologydescription
Background The molecular mechanisms that determine the organism's response to a variety of doses and modalities of stress factors are not well understood. Results We studied effects of ionizing radiation (144, 360 and 864 Gy), entomopathogenic fungus (10 and 100 CFU), starvation (16 h), and cold shock (+4, 0 and -4°C) on an organism's viability indicators (survival and locomotor activity) and transcriptome changes in the Drosophila melanogaster model. All stress factors but cold shock resulted in a decrease of lifespan proportional to the dose of treatment. However, stress-factors affected locomotor activity without correlation with lifespan. Our data revealed both significant similarities and differences in differential gene expression and the activity of biological processes under the influence of stress factors. Conclusions Studied doses of stress treatments deleteriously affect the organism's viability and lead to different changes of both general and specific cellular stress response mechanisms.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-12-01 | BMC Genomics |