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RESEARCH PRODUCT

Mammalian Pinealocytes: Ultrastructural Aspects and Innervation

subject

description

In the mammalian pineal gland it is notoriously difficult to relate structure to function. The pineal-specific cells, the pinealocytes, contain only inconspicuous numbers of secretory granules, and the variable amounts of smooth and rough endoplasmic reticulum also do not point to a particular function. In addition to these widely known cellular components, pinealocytes contain organelles, the so-called 'synaptic' ribbons, histophysiological studies of which provide important insights into the structural and functional complexity of the organ. As synaptic ribbons may be involved in neuronal functions of pinealocytes it is notable that these organelles are structurally heterogeneous. Ribbons fall into at least two categories: rod-like (RSR) and sphere-like (SS) structures. RSR and SS usually do not lie within the same pinealocyte profile and appear to be regulated by different mechanisms. It is conceivable that they are important components of the biological clock system. These findings are related to our knowledge of the innervation of the mammalian pineal gland and to electrophysiological characteristics of pinealocytes.