6533b82cfe1ef96bd128f437
RESEARCH PRODUCT
Lithium enediolates and dienediolates of carboxylic acids in synthesis: Alkylation with secondary halides
Eva M. BrunSalvador GilMargarita ParraRamon Mestressubject
chemistry.chemical_classificationDouble bondChemistryOrganic Chemistrychemistry.chemical_elementHalideAlkylationBiochemistryElimination reactionDrug DiscoveryOrganic chemistrylipids (amino acids peptides and proteins)Rather poorStereoselectivityLithiumdescription
Abstract High yields in the alkylation of dianions of α,β-unsaturated carboxylic acids with secondary halides can be obtained despite elimination reactions occurring. α-Regioselectivity for the alkylation of but-2-enoic acids ( 1–4 ) is seldom obtained. Although double bond stereoselectivity is higher than 99% for γ-alkylated products, stereoselectivity is rather poor for most of the α-alkylated products.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1998-12-01 | Tetrahedron |