6533b82cfe1ef96bd128f49e

RESEARCH PRODUCT

Enzyme-Controlled Nanodevice for Acetylcholine-Triggered Cargo Delivery Based on Janus Au–Mesoporous Silica Nanoparticles

Paula DíezReynaldo VillalongaReynaldo VillalongaPaloma Martínez-ruizMaría Dolores MarcosMaría Dolores MarcosCristina De La TorreCristina De La TorreAntoni Llopis-lorenteAntoni Llopis-lorenteRamón Martínez-máñezRamón Martínez-máñezFélix SancenónFélix SancenónAlfredo SánchezAlfredo SánchezElena AznarElena Aznar

subject

Cell SurvivalSupramolecular chemistryNanoparticleNanotechnologymacromolecular substances02 engineering and technology010402 general chemistry01 natural sciencesCatalysisQUIMICA ORGANICACIENCIA DE LOS MATERIALES E INGENIERIA METALURGICAQUIMICA ANALITICAmedicineOrganometallic CompoundsControlled releaseNanotechnologyHumansJanusNanodevicechemistry.chemical_classificationDrug CarriersChemistryHydrolysisQUIMICA INORGANICAOrganic Chemistrybeta-CyclodextrinsGeneral ChemistryMesoporous silicaHydrogen-Ion Concentration021001 nanoscience & nanotechnologyEnzymes ImmobilizedSilicon DioxideControlled releaseMesoporous materialsAcetylcholine0104 chemical sciencesEnzymeDoxorubicinAcetylcholinesteraseNanoparticlesBenzimidazolesGold0210 nano-technologyPorosityAcetylcholinemedicine.drugHeLa Cells

description

[EN] This work reports a new gated nanodevice for acetylcholine-triggered cargo delivery. We prepared and characterized Janus Au-mesoporous silica nanoparticles functionalized with acetylcholinesterase on the Au face and with supramolecular b-cyclodextrin: benzimidazole inclusion complexes as caps on the mesoporous silica face. The nanodevice is able to selectively deliver the cargo in the presence of acetylcholine via enzyme-mediated acetylcholine hydrolysis, locally lowering the pH and opening the supramolecular gate. Given the key role played by ACh and its relation with Parkinson's disease and other nervous system diseases, we believe that these findings could help design new therapeutic strategies.

yearjournalcountryeditionlanguage
2017-01-01
http://hdl.handle.net/20.500.12614/1422