6533b82cfe1ef96bd128f6b7
RESEARCH PRODUCT
Burden of non-communicable diseases among adolescents aged 10-24 years in the EU, 1990-2019: a systematic analysis of the Global Burden of Diseases Study 2019
Benedetta ArmocidaLorenzo MonastaSusan SawyerFlavia BustreoGiulia SegafredoGiulio CastelpietraLuca RonfaniMaja PasovicSimon HayPablo PerelDavid BeranBenedetta ArmocidaLorenzo MonastaSusan M. SawyerFlavia BustreoGiulia SegafredoGiulio CastelpietraLuca RonfaniMaja PasovicSimon I. HayDerrick Bary AbilaHassan AbolhassaniManfred Mario Kokou AccrombessiVictor AdekanmbiKeivan AhmadiHanadi Al HamadMamoon A. AldeyabAdel Al-jumailyRobert AncuceanuCatalina Liliana AndreiTudorel AndreiAshokan ArumugamSameh AttiaAvinash AujayebMarcel AusloosJennifer L. BakerFrancesco Barone-adesiFabio BarraSandra BarteitSanjay BasuBernhard T. BauneYannick BéjotLuis BeloDerrick A. BennettBoris BikbovAndras BikovOleg BlyussSusanne BreitnerHermann BrennerGiulia CarrerasMárcia CarvalhoAlberico L. CatapanoJoht Singh ChandanPeriklis CharalampousSimiao ChenJoao CondeNatália Cruz-martinsGiovanni DamianiAnna DastiridouAlejandro De La Torre-luqueMostafa DianatinasabDiana Dias Da SilvaAbdellah DouiriElena DragiotiLuchuo Engelbert BainAdeniyi Francis FagbamigbeSeyed-mohammad FereshtehnejadPietro FerraraJosé Miguel P. Ferreira De OliveiraSimone FerreroLorenzo Ferro DesideriFlorian FischerDiogo FonsecaPiyada GaewkhiewSantosh GaihreSilvano GallusMariana Gaspar FonsecaParamjit GillJames C. GlasbeyGiuseppe GoriniVijai Kumar GuptaMekdes Kondale GuraraJosep Maria HaroM Tasdik HasanRasmus J. HavmoellerBehzad HeibatiMerel E. HellemonsClaudiu HerteliuSalman HussainGaetano IsolaOlatunji JohnsonJost B. JonasJacek Jerzy JozwiakMikk JürissonZubair KabirAndré KarchJoonas H. KauppilaGbenga A. KayodeMoien A. B. KhanKhaled KhatabMika KivimäkiMiloslav KlugarJitka KlugarováKamrun Nahar KolyAi KoyanagiOm P. KurmiDian KusumaCarlo La VecchiaBen LaceyTea LallukkaDemetris LamnisosBerthold LangguthAnders O. LarssonPaolo LauriolaPaul H. LeeMatilde LeonardiAn LiChristine LinehanRubén López-buenoStefan LorkowskiJoana A. LoureiroRaimundas LuneviciusLaura A. MageeFrancesca Giulia MagnaniAzeem MajeedKonstantinos Christos MakrisAlexander G. MathioudakisManu Raj MathurJohn J. McgrathRitesh G. MenezesAlexios-fotios A. MentisAtte MeretojaTomislav MestrovicJunmei Miao JonassonTomasz MiazgowskiAndreea MiricaMarcello MocciaShafiu MohammedMariam MolokhiaStefania MondelloUlrich Otto MuellerFrancesk MulitaDaniel MunblitIonut NegoiRuxandra Irina NegoiEvangelia NenaNurulamin M. NoorChristoph NowakGeorge NtaiosVincent Ebuka NwatahBogdan OanceaAyodipupo Sikiru OguntadeAlberto OrtizAdrian OtoiuAlicia Padron-monederoRaffaele PalladinoAdrian PanaDemosthenes PanagiotakosSonghomitra Panda-jonasShahina PardhanJay PatelPaolo PedersiniJosé L. PeñalvoUmberto PensatoRenato B. PereiraNorberto PericoIonela-roxana PetcuSuzanne PolinderMaarten J. PostmaMohammad RabieeNavid RabieeAlberto RaggiShadi RahimzadehDavid Laith RawafSalman RawafFaizan Ur RehmanGiuseppe RemuzziAbanoub RiadAlina RodriguezSimona SaccoMohammad Reza SaebMahdi SafdarianBrijesh SathianDavide SattinSonia SaxenaNikolaos ScarmeasWinfried SchleeFalk SchwendickeMorteza ShamsizadehNigussie Tadesse SharewRahman ShiriSiddharudha ShivalliVelizar ShivarovJoão Pedro SilvaColin R. SimpsonSøren T SkouBogdan SoceaIreneous N. SoyiriPaschalis SteiropoulosKurt StraifXiaohui SunRafael Tabarés-seisdedosArulmani ThiyagarajanFotis TopouzisMarcos Roberto Tovani-paloneThomas Clement TruelsenBrigid UnimJef Van Den EyndeTommi Juhani VasankariMassimiliano VerouxSantos VillafainaMatej VinkoFrancesco S. ViolanteVictor VoloviciYanzhong WangRonny WestermanMohammad Esmaeil YadegarfarSanni YayaVesna ZadnikAlimuddin ZumlaPablo PerelDavid BeranHash(0x5651c96cd260)subject
Malemortality burdenAdolescentRJRJ101CareGlobal Burden of DiseaseLife ExpectancyRJ101 Child Health. Child health servicesSDG 3 - Good Health and Well-beingRA04213123 Gynaecology and paediatricsRisk FactorsRA0421 Public health. Hygiene. Preventive MedicineDevelopmental and Educational PsychologyHumansDisabled PersonsNoncommunicable DiseasesFutureDeterminantsMCCDisabilityPublic Health Global Health Social Medicine and EpidemiologyBurden of non-communicable diseases among adolescents aged 10–24 years in the EU 1990–2019: a systematic analysis of the Global Burden of Diseases Study 20193rd-DASDisability; mortality burdenFolkhälsovetenskap global hälsa socialmedicin och epidemiologin/aHealthPediatrics Perinatology and Child HealthFemaleRAdescription
Background: Disability and mortality burden of non-communicable diseases (NCDs) have risen worldwide; however, the NCD burden among adolescents remains poorly described in the EU. Methods: Estimates were retrieved from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Causes of NCDs were analysed at three different levels of the GBD 2019 hierarchy, for which mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) were extracted. Estimates, with the 95% uncertainty intervals (UI), were retrieved for EU Member States from 1990 to 2019, three age subgroups (10–14 years, 15–19 years, and 20–24 years), and by sex. Spearman's correlation was conducted between DALY rates for NCDs and the Socio-demographic Index (SDI) of each EU Member State. Findings: In 2019, NCDs accounted for 86·4% (95% uncertainty interval 83·5–88·8) of all YLDs and 38·8% (37·4–39·8) of total deaths in adolescents aged 10–24 years. For NCDs in this age group, neoplasms were the leading causes of both mortality (4·01 [95% uncertainty interval 3·62–4·25] per 100 000 population) and YLLs (281·78 [254·25–298·92] per 100 000 population), whereas mental disorders were the leading cause for YLDs (2039·36 [1432·56–2773·47] per 100 000 population) and DALYs (2040·59 [1433·96–2774·62] per 100 000 population) in all EU Member States, and in all studied age groups. In 2019, among adolescents aged 10–24 years, males had a higher mortality rate per 100 000 population due to NCDs than females (11·66 [11·04–12·28] vs 7·89 [7·53–8·23]), whereas females presented a higher DALY rate per 100 000 population due to NCDs (8003·25 [5812·78–10 701·59] vs 6083·91 [4576·63–7857·92]). From 1990 to 2019, mortality rate due to NCDs in adolescents aged 10–24 years substantially decreased (–40·41% [–43·00 to –37·61), and also the YLL rate considerably decreased (–40·56% [–43·16 to –37·74]), except for mental disorders (which increased by 32·18% [1·67 to 66·49]), whereas the YLD rate increased slightly (1·44% [0·09 to 2·79]). Positive correlations were observed between DALY rates and SDIs for substance use disorders (rs=0·58, p=0·0012) and skin and subcutaneous diseases (rs=0·45, p=0·017), whereas negative correlations were found between DALY rates and SDIs for cardiovascular diseases (rs=–0·46, p=0·015), neoplasms (rs=–0·57, p=0·0015), and sense organ diseases (rs=–0·61, p=0·0005). Interpretation: NCD-related mortality has substantially declined among adolescents in the EU between 1990 and 2019, but the rising trend of YLL attributed to mental disorders and their YLD burden are concerning. Differences by sex, age group, and across EU Member States highlight the importance of preventive interventions and scaling up adolescent-responsive health-care systems, which should prioritise specific needs by sex, age, and location. Funding: Bill & Melinda Gates Foundation.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2022-06-01 |