6533b82cfe1ef96bd128fe06
RESEARCH PRODUCT
New Reactions of Amino-Functionalized 3-Vinyl-1H-indoles and Tetrahydropyridin-4-yl Analogues with Dienophiles
Mercedes Medion-simonUlf Pindursubject
Bicyclic moleculeChemistryOrganic ChemistryBiochemistryRedoxCatalysisQualitative predictionAmino functionalizedAdductEnamineInorganic Chemistrychemistry.chemical_compoundDrug DiscoveryOrganic chemistryPhysical and Theoretical ChemistryEne reactiondescription
Reactions of 3-[2-(morpholin-4-yl)vinyl]-1H-indole (1), the 1,2-dihydro-9H-carbazole 2, as well as the 3-(tetrahydropyridin-4-yl)-1H-indoles 3a and 3b with some carbo- and heterodienophiles are described. The scope and limitations of the synthetic utility of these amino- (or homoamino)-functionalized 3-vinyl-1H-indoles are reported and some MO calculations for the qualitative prediction of their reactivities are presented. The reactions gave rise to substitution products, redox products, Diels-Alder adducts, ene adducts, and Michael-type adducts (Schemes 2 and 3).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1991-03-13 | Helvetica Chimica Acta |