6533b82cfe1ef96bd128fe5d
RESEARCH PRODUCT
Molecular and crystal structure of Nα-(9-fluorenyl)-methoxycarbonyl-L-ornithine hydrochloride diethyl ether solvate
Elzbieta MasiukiewiczLiliana MazurBarbara RzeszotarskaAnna E. Koziolsubject
HydrochlorideHydrogen bondStereochemistryL-OrnithineBioengineeringCrystal structureOrnithineBiochemistryMedicinal chemistryAnalytical Chemistrychemistry.chemical_compoundchemistryDrug DiscoverySide chainMolecular MedicineMoleculeDiethyl etherdescription
The solid-state conformation of the first N-protected ornithine derivative has been established by X-ray analysis. The hydrochloride of Nα-(9-fluorenyl)methoxycarbonyl-l-ornithine crystallises as diethyl ether solvate. The backbone (ω0 ϕ, ψ χ1) torsion angles are (174.9°,–84.0°, 145.9°,–171.0°). The conformation of the urethane amide bonds istrans. The ornithine aliphatic side chain adopts preferred fully extended conformation which is stabilised by the hydrogen bonding of the-NH3+ group to the diethyl ether molecule, carboxyl group and Cl− anions.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2002-11-01 | Letters in Peptide Science |