6533b82cfe1ef96bd128ff7d

RESEARCH PRODUCT

Bioactive extracts from persimmon waste: influence of extraction conditions and ripeness

Albert Ribas-agustíMassimo CastellariAmparo López-rubioMaría José FabraGloria SánchezPaula AranazCarlos J González-navarroIrene FalcóAriane VettorazziDaniel Alexander MéndezAntonio Martínez-abad

subject

0301 basic medicinePersimmon663/664AntioxidantCentral composite designFood HandlingExtractmedicine.medical_treatmentved/biology.organism_classification_rank.speciesPhenolic contentRipenessAntiviral AgentsAntioxidantsMice03 medical and health sciences0404 agricultural biotechnologyPhenolsAntioxidant activitymedicineAnimalsPersimmon extractFood scienceCaenorhabditis elegansWaste Products030109 nutrition & dieteticsPlant Extractsved/biologyChemistryNorovirusExtraction (chemistry)Proteins04 agricultural and veterinary sciencesGeneral MedicineDiospyros040401 food scienceVirusDisease Models AnimalFruitaToxicityComposition (visual arts)Food ScienceMurine norovirus

description

In this work, a bioactive persimmon extract was produced from discarded fruits. A central composite design was used to evaluate the effect of different extraction parameters and ripeness stages of persimmon fruits on the total phenolic content and antioxidant activity of the resulting extracts. Significantly greater phenolic contents were obtained from immature persimmon (IP) fruits. The optimum IP extract with the conditions set by the experimental design was industrially up-scaled and its composition and functional properties were evaluated and compared with those obtained under lab-scale conditions. Both extracts contained significant protein (>20%) and phenolic contents (∼11–27 mg GA/g dry extract) and displayed significant antiviral activity against murine norovirus and hepatitis A virus. Moreover, the extract showed no toxicity and significantly reduced the fat content and the cellular ageing of Caenorhabditis elegans (C. elegans) without affecting the worm development. These effects were mediated by down-regulation of fat-7, suggesting an anti-lipogenic activity of this extract.

yearjournalcountryeditionlanguage
2021-06-01Food & Function
https://doi.org/10.1039/d1fo00457c