6533b82cfe1ef96bd128ffc4

RESEARCH PRODUCT

Lack of hepatitis B virus DNA sequences in sera from patients with acute and chronic liver diseases diagnosed as non-A, non-B-hepatitis

Georg HessK H Meyer Zum BüschenfeldeJ. SlusarczykBengt-göran Hansson

subject

AdultMaleHepatitis B virusAdolescentHepatitis Viral HumanDot blotmedicine.disease_causeChronic liver diseaseVirusPlasmidmedicineHumansFalse Positive ReactionsAgedHepatitis B virusHepatologybiologybusiness.industryMiddle AgedHepatitis Bmedicine.diseasebiology.organism_classificationHepatitis CVirologyHepadnaviridaeDNA ViralImmunologyFemaleViral diseasebusiness

description

— The sera of 15 individuals with transfusion-associated acute or chronic non A, non B hepatitis, which lacked hepatitis B virus markers, were tested for hepatitis B virus DNA by dot blot hybridization test. Three sera of two patients positive in this test, however, also gave positive results when the labeled plasmid was used as probe instead of labeled HBV-DNA, indicating false positive results in the initial test. In conclusion, the data indicated that sera of patients with confirmed non A, non B hepatitis do not contain DNA-sequences in the serum hybridizing with HBV-DNA.

yearjournalcountryeditionlanguage
2008-12-10Liver
https://doi.org/10.1111/j.1600-0676.1986.tb00301.x