6533b82cfe1ef96bd128ffe0

RESEARCH PRODUCT

Binucleate cells in the Ehrlich ascites tumor. Action of 5-fluorouracil.

José A. PellicerVicente AlcoberJosé Pertusa

subject

Cell NucleusDose-Response Relationship DrugCell BiologyGeneral MedicineBiologyPharmacologyEhrlich ascitesMiceFluorouracilImmunologymedicineMitotic IndexDistribution (pharmacology)AnimalsFemaleFluorouracilCarcinoma Ehrlich TumorAfter treatmentmedicine.drug

description

Time-dependent frequency distribution of binucleate cells (BC) was studied in Ehrlich ascites tumor (EAT) growing in mice. In animals that received no further treatment, the number of BC increased slowly from 2.6% to 16.5% of total cells within 8 days. In animals that were treated with different doses of 5-fluorouracil (FU) we found clearly higher numbers of BC. The number of BC increased with tumor age. The increase observed after treatment was reached more quickly in animals that had received the highest FU dose. The final number of BC was also dependent on the age of the tumor at the time of FU injection.

yearjournalcountryeditionlanguage
1987-01-01Biology of the cell
10.1111/j.1768-322x.1987.tb00561.xhttps://pubmed.ncbi.nlm.nih.gov/2962683