6533b82cfe1ef96bd12900de
RESEARCH PRODUCT
Desaturase activities are depleted before and after weaning in liver microsomes of spontaneously hypertensive rats
Michel NarceV. FustierJ.-l. SavelliJ.-p. Poissonsubject
Blood GlucoseFatty Acid DesaturasesMalemedicine.medical_specialtyTime FactorsLinoleic acidClinical BiochemistryWeaningBiologyRats Inbred WKYchemistry.chemical_compoundRats Inbred SHRInternal medicinemedicineAnimalsWeaningcardiovascular diseaseschemistry.chemical_classificationArachidonic AcidBody WeightCell Biologybiology.organism_classificationRatsEndocrinologyEnzymeLinoleic AcidschemistryMicrosomaData Interpretation StatisticalHypertensionMicrosomes Livercardiovascular systemMicrosomeFemaleArachidonic acidLinoleoyl-CoA desaturasecirculatory and respiratory physiologyHormonedescription
Abstract In the present study, we have investigated the microsomal linoleic acid desaturation steps into arachidonic acid in 10- and 30-day-old spontaneously hypertensive rats (SHR), as compared to their normotensive control rats, Wistar Kyoto (WKY). Suckled by adoptive Wistar normotensive female, the SHR and WKY were fed the same diet. Our results show lower Δ6 and Δ5 desaturase activities (the limiting steps in the bioconversion of linoleic acid into arachidonic acid) in the young SHR, as compared to the WKY normotensive rats. The fatty acid composition of liver microsomal total lipids evidences a higher proportion of linoleic acid in SHR than in WKY, in agreement with the partially depleted desaturase activities. Such a loss of desaturase activities may be under the control of hormones involved in the regulation of SHR blood pressure.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2002-07-30 | Prostaglandins, Leukotrienes and Essential Fatty Acids |