0000000000706885

AUTHOR

V. Fustier

showing 2 related works from this author

Desaturase activities are depleted before and after weaning in liver microsomes of spontaneously hypertensive rats

2002

Abstract In the present study, we have investigated the microsomal linoleic acid desaturation steps into arachidonic acid in 10- and 30-day-old spontaneously hypertensive rats (SHR), as compared to their normotensive control rats, Wistar Kyoto (WKY). Suckled by adoptive Wistar normotensive female, the SHR and WKY were fed the same diet. Our results show lower Δ6 and Δ5 desaturase activities (the limiting steps in the bioconversion of linoleic acid into arachidonic acid) in the young SHR, as compared to the WKY normotensive rats. The fatty acid composition of liver microsomal total lipids evidences a higher proportion of linoleic acid in SHR than in WKY, in agreement with the partially deple…

Blood GlucoseFatty Acid DesaturasesMalemedicine.medical_specialtyTime FactorsLinoleic acidClinical BiochemistryWeaningBiologyRats Inbred WKYchemistry.chemical_compoundRats Inbred SHRInternal medicinemedicineAnimalsWeaningcardiovascular diseaseschemistry.chemical_classificationArachidonic AcidBody WeightCell Biologybiology.organism_classificationRatsEndocrinologyEnzymeLinoleic AcidschemistryMicrosomaData Interpretation StatisticalHypertensionMicrosomes Livercardiovascular systemMicrosomeFemaleArachidonic acidLinoleoyl-CoA desaturasecirculatory and respiratory physiologyHormoneProstaglandins, Leukotrienes and Essential Fatty Acids
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Liver oleic acid biogenesis is impaired during the prehypertensive period in the spontaneously hypertensive rat.

2003

In the present study, we have investigated the liver microsomal stearic acid delta9 desaturation, and the fatty acid composition of liver microsomal total lipids in 10- and 30-day-old spontaneously hypertensive rats (SHRs), compared to the normotensive Wistar Kyoto (WKY) control rats. So as to avoid any influence related to the diet, the composition of the milk being different in SHR and WKY strains, the pups were suckled by adoptive normotensive female Wistar. After weaning, the 30-day-old rats were fed a standard commercial diet and then killed. Our results show lower liver microsomal delta9 desaturase activities in the 10- and 30-day-old SHR versus the WKY of the same age. The fatty acid…

Blood GlucoseFatty Acid DesaturasesMalemedicine.medical_specialtyAgingClinical BiochemistryBiologyRats Inbred WKYchemistry.chemical_compoundSpontaneously hypertensive ratInternal medicineRats Inbred SHRmedicineWeaningAnimalsRats WistarBody WeightFatty AcidsLipid metabolismCell BiologyOrgan SizeRatsOleic acidEndocrinologyEicosanoidchemistryAnimals NewbornLiverHypertensionMicrosomeMicrosomes LiverStearic acidStearoyl-CoA DesaturaseHormoneOleic AcidProstaglandins, leukotrienes, and essential fatty acids
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