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RESEARCH PRODUCT
A gelatin-thrombin matrix topical hemostatic agent (Floseal) in combination with harmonic scalpel is effective in patients undergoing total thyroidectomy: A prospective, multicenter, single-blind, randomized controlled trial
Giovanni DocimoSalvatore ToloneGiovanni ConzoPaolo LimongelliGianmattia Del GenioDomenico ParmeggianiDe Palma MLupone GAvenia NLucchini RMonacelli MGulotta GScerrino GDaniela PasqualiGiuseppe BellastellaKatherine EspositoAnnamaria De BellisPezzolla ARoberto RuggieroDocimo L. : A. Gelatin Thrombin Matrix Topical Hemostatic Agent In Combination With Harmonic Scalpel Is Effective In Patients Undergoing Total Thyroidectomy: A. ProspectiveMulticenterSingle BlindRandomized Controlled T.r.i.a.l. Surg I.n.n.o.v. 2015 Aug 3. Pii: 1.5.5.3.3.5.0.6.1.5.5.9.6.6.3.8. [Epub Ahead Of Print] Pmid: 26243629subject
AdultMalemedicine.medical_specialtyfood.ingredientmedicine.medical_treatmenthemostatic agent030230 surgeryGelatinHemostaticslaw.invention03 medical and health sciencesHemostatic0302 clinical medicinefoodThrombinRandomized controlled triallawHarmonic scalpelHumansMedicineProspective StudiesProspective cohort studyFloseal; gelatin-thrombin matrix; harmonic scalpel; hemostatic agent; total thyroidectomy;Hemostatic Agentbusiness.industryharmonic scalpelThrombinThyroidectomygelatin-thrombin matrixMiddle AgedSurgical InstrumentsGelatin Sponge AbsorbableSurgerytotal thyroidectomyProspective StudieTreatment Outcome030220 oncology & carcinogenesisHemostasisAnesthesiaThyroidectomyGelatinFemaleSurgerybusinessFlosealHumanmedicine.drugdescription
BACKGROUND: Hemostasis during thyroidectomy is essential; however, the safest, most efficient, and most cost-effective way to achieve this is unclear. This randomized, multicenter, single-blind, prospective study evaluated the efficacy and safety of using different hemostatic approaches in patients undergoing total thyroidectomy. METHODS: Patients aged ≥18 to 70 years were randomized to Floseal + a harmonic scalpel (HS), Floseal alone, HS alone, or standard total thyroidectomy. Primary endpoint was 24-hour drain output. Secondary endpoints included surgery duration and complications. RESULTS: Two hundred and six patients were randomized to Floseal + HS (n = 52), Floseal alone (n = 54), HS alone (n = 50), and standard total thyroidectomy (n = 50). The 24-hour drain output was lower in the Floseal + HS group compared with standard thyroidectomy. Floseal + HS also had a shorter surgery time (P < .0001) versus the other 3 treatments. CONCLUSION: Floseal + HS can be effective at reducing postsurgical drain output and provides a complementary hemostatic approach in patients undergoing total thyroidectomy. © The Author(s) 2015. Background. Hemostasis during thyroidectomy is essential; however, the safest, most efficient, and most cost-effective way to achieve this is unclear. This randomized, multicenter, single-blind, prospective study evaluated the efficacy and safety of using different hemostatic approaches in patients undergoing total thyroidectomy. Methods. Patients aged ≥18 to 70 years were randomized to Floseal + a harmonic scalpel (HS), Floseal alone, HS alone, or standard total thyroidectomy. Primary endpoint was 24-hour drain output. Secondary endpoints included surgery duration and complications. Results. Two hundred and six patients were randomized to Floseal + HS (n = 52), Floseal alone (n = 54), HS alone (n = 50), and standard total thyroidectomy (n = 50). The 24-hour drain output was lower in the Floseal + HS group compared with standard thyroidectomy. Floseal + HS also had a shorter surgery time (P <.0001) versus the other 3 treatments. Conclusion. Floseal + HS can be effective at reducing postsurgical drain output and provides a complementary hemostatic approach in patients undergoing total thyroidectomy.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-01-01 |