6533b82dfe1ef96bd12907bc
RESEARCH PRODUCT
Conformational preferences of side-chain protected amino acid residues and their impact in peptide synthesis
B. KleinClaudio TonioloFranz MaserManfred MutterGian Maria Bonorasubject
chemistry.chemical_classificationStereochemistryOrganic ChemistryBiophysicsPeptidemacromolecular substancesGeneral MedicineBiochemistryBiomaterialschemistry.chemical_compoundchemistrySide chainPeptide synthesisSolubilityAmino acid residuePeptide sequencedescription
Using the host-guest technique, tentative scales for the helix-inducing power and the β-structure-forming potential of various side-chain protected amino acid residues in trifluoro-ethanol are established mainly by CD measurements. The generally lower tendency for β-structure formation of the host–guest peptides compared to that of the host peptide is discussed. The influence of these conformational features on the solubility of the peptides is also pointed out.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1983-01-01 | Biopolymers |