6533b82dfe1ef96bd1290812

RESEARCH PRODUCT

Covalently linked multi-calixarenes

Gabriel RokickiVolker BöhmerMaija NissinenKari RissanenOliver MogckPaweł G. Parzuchowski

subject

chemistry.chemical_compoundchemistryCovalent bondStereochemistryDendrimerOrganic ChemistryDrug DiscoveryCalixarenePolymer chemistryBiochemistryDerivative (chemistry)First generation

description

Abstract ipso-Nitration of t-butyl calix[4]arene tetraethers and subsequent hydrogenation provides an easy access to monoamino calix[4]arenes. Reaction with di- and triacid chlorides leads to various double- and triple-calix[4]arenes. With tetraacid chlorides derived from calix[4]arenes in the cone- or 1,3-alternate-conformations penta-calix[4]arenes are available as molecularly uniform species, which may be regarded as the first generation of calix[4]arene based dendrimers. The structure of the mononitro tetraester derivative, which may serve as a general building block has been confirmed by single crystal X-ray analysis.

yearjournalcountryeditionlanguage
1998-08-01Tetrahedron
https://doi.org/10.1016/s0040-4020(98)00594-8