6533b82dfe1ef96bd129091e

RESEARCH PRODUCT

Spectrophotometric determination of promethazine by flow injection analysis and oxidation by CeIV

J. Martínez CalatayudT. García Sancho

subject

Flow injection analysisChromatographymedicine.diagnostic_testChemistryClinical BiochemistryPromethazine HydrochloridePharmaceutical ScienceCeriumPharmaceutical formulationPromethazineDosage formAnalytical ChemistryPromethazineAbsorbanceInvestigation methodsSpectrophotometrySpectrophotometryFlow Injection AnalysisDrug DiscoverymedicineOxidation-ReductionSpectroscopymedicine.drug

description

A flow injection analysis (FIA) procedure is proposed for the determination of promethazine. The sample solution is directly injected into the carrier-reagent stream which comprises a solution of ceric ions in a sulphuric acid medium. The absorbance at 514 nm from the red colour developed by the oxidation of promethazine is measured. Effects of foreign substances have been investigated and the procedure has been applied to the determination of promethazine in a pharmaceutical formulation (tablets).

yearjournalcountryeditionlanguage
1992-01-01Journal of Pharmaceutical and Biomedical Analysis
https://doi.org/10.1016/0731-7085(92)80008-b