6533b82dfe1ef96bd12909cc
RESEARCH PRODUCT
Facile synthesis of annulated heterocyclic benzo[kl]acridine derivatives via one-pot N–H/C–H coupling
Yulian ZagranyarskiYulian ZagranyarskiKlaus MüllenKlaus MüllenArtem SkabeevChen LiYingjie Masubject
010405 organic chemistryChemistryOrganic ChemistryAcridine derivatives010402 general chemistry01 natural sciencesMedicinal chemistryDomino0104 chemical sciencesCatalysisCoupling (electronics)Yield (chemistry)Organic chemistryAminationdescription
An efficient N–H/C–H one-pot coupling method for the preparation of benzo[kl]acridines has been developed based on palladium-catalyzed domino synthesis. Using commercially available starting materials such as dihalonaphthalenes and diphenylamines, and combining amination with catalysts for C–H activation, up to 95% overall yield can be achieved.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-01-01 | Organic Chemistry Frontiers |