6533b82dfe1ef96bd12909f5
RESEARCH PRODUCT
Effect of a "therapeutic" concentration of digitoxigenine on myocardial potassium and sodium content in Ca-poor media.
H. Scholzsubject
PharmacologyMalemedicine.medical_specialtySalt contentChemistryPotassiumMyocardiumPharmacology toxicologyGuinea PigsSodiumchemistry.chemical_elementWaterHeartGeneral MedicineIn Vitro TechniquesEndocrinologyInternal medicineExtracellularmedicinePotassiumAnimalsCardanolidesCalciumFemaleExtracellular Spacedescription
The effect of 3·10−7 g/ml digitoxigenine on cellular K and Na concentrations, [K]i and [Na]i, water content, extracellular space, and contractile force was investigated in isolated electrically stimulated left guinea-pig auricles at reduced extracellular Ca concentration (0.45 mM). Digitoxigenine, which increased contractile force without producing arrhythmias or contractures, decreased [K]i and enhanced [Na]i. Water content and extracellular space remained unchanged. It is concluded that digitoxigenine can decrease myocardial [K]i and increase [Na]i even in “therapeutic” concentrations, provided that the experiments are performed in Ca-poor media.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1972-01-01 | Naunyn-Schmiedeberg's archives of pharmacology |