6533b82dfe1ef96bd1290a09
RESEARCH PRODUCT
Phytotoxic Lignans from Artemisia arborescens
Andrea LabruzzoAbbas AliStephen O. DukeDavid E. WedgeCharles L. CantrellAlessandra Carrubbasubject
PharmacologyChromatographybiology010405 organic chemistryChemistryfungiArtemisia arborescens Allelopathy Herbicidal Phytotoxicity Lactone Lignans Ashantin Sesaminfood and beveragesPlant ScienceGeneral MedicineFractionationArtemisia arborescensbiology.organism_classification01 natural sciencesChlorideSettore AGR/02 - Agronomia E Coltivazioni Erbacee0104 chemical sciences010404 medicinal & biomolecular chemistrychemistry.chemical_compoundComplementary and alternative medicineDrug DiscoverymedicineMethylenemedicine.drugdescription
A systematic bioassay-guided fractionation of methylene chloride extracts of the aerial part of Artemisia arborescens was performed in order to identify its phytotoxic compounds Two lignans were isolated, sesamin and ashantin, that inhibited growth of Agrostis stolonifera (bentgrass), a monocot, and Lactuca sativa (lettuce), a dicot, at 1 mg mL–1. In a dose-response screening of these lignans for growth inhibition against Lemna paucicostata (duckweed), ashantin was the most active with an IC50 of ca. 224 μM. The mode of action of these compounds is still unknown. In mosquito larvicidal bioassays the pure compounds sesamin and ashantin did not cause mortality at the highest dose of 125 mg/L against 1-d-old Aedes aegypti larvae. In bioautography bioassays for antifungal activity using Botrytis cinerea, Fusarium oxysporum, Colletotrichum fragariae, Colletotrichum acutatum, and Colletotrichum gloeosporioides, ashantin and sesamin were inactive at 5 μg and were therefore not subjected to additional screening in secondary antifungal assays.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-03-01 | Natural Product Communications |