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RESEARCH PRODUCT
Use of Super Paramagnetic Iron Oxide Nanoparticles as Drug Carriers in Brain and Ear: State of the Art and Challenges
Caroline GuigouNadine MillotKarim BelharetAlexis Bozorg GrayeliKibrom Berihu GirumGilles CrehangeAlain Lalandesubject
blood–perilymph barrierinner earDrugMaterials scienceBiocompatibilitySuperparamagnetic iron oxide nanoparticlesmedia_common.quotation_subjectNanotechnologyReviewblo-od–brain barrier02 engineering and technologylcsh:RC321-57103 medical and health scienceschemistry.chemical_compoundblood–perilymph barrier[INFO.INFO-IM]Computer Science [cs]/Medical ImagingDistribution (pharmacology)lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry030304 developmental biologymedia_common0303 health sciencesGeneral Neuroscienceiron oxide nanoparticlescentral nervous system021001 nanoscience & nanotechnology3. Good healthchemistrydrug deliveryDrug deliveryblood–brain barriersense organsNanocarriers0210 nano-technologyDrug carrierIron oxide nanoparticlesdescription
International audience; Drug delivery and distribution in the central nervous system (CNS) and the inner ear represent a challenge for the medical and scientific world, especially because of the blood–brain and the blood–perilymph barriers. Solutions are being studied to circumvent or to facilitate drug diffusion across these structures. Using superparamagnetic iron oxide nanoparticles (SPIONs), which can be coated to change their properties and ensure biocompatibility, represents a promising tool as a drug carrier. They can act as nanocarriers and can be driven with precision by magnetic forces. The aim of this study was to systematically review the use of SPIONs in the CNS and the inner ear. A systematic PubMed search between 1999 and 2019 yielded 97 studies. In this review, we describe the applications of the SPIONS, their design, their administration, their pharmacokinetic, their toxicity and the methods used for targeted delivery of drugs into the ear and the CNS.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-03-01 | Brain Sciences |