Ceftazidime Determination in Serum by High-pressure Liquid Chromatography

6533b82dfe1ef96bd1290afb

RESEARCH PRODUCT

Ceftazidime Determination in Serum by High-pressure Liquid Chromatography

Till Humbert Ulrich Fauth Andreas Rümelin

subject

Peak area Detection limit Chromatography Chemistry Reproducibility of Results Ceftazidime Reference Standards Ceftazidime High-performance liquid chromatography Cephalosporins Linear relationship Simple sample Drug Discovery medicine Humans Quantitative analysis (chemistry)Chromatography High Pressure Liquid medicine.drug Antibacterial agent

description

A rapid and sensitive high-pressure liquid chromatographic method with simple sample preparation was developed for the quantitative analysis of the beta-lactam antibiotic ceftazidime (CAS 78439-06-2, Fortum). A good linear relationship was established between the peak area and the amount of ceftazidime injected over a concentration range of 1 to 200 microg/ml. The detection limit of the method was calculated to be 0.9 microg/ml. Stability was shown at 4 degrees C and at -196 degrees C for time periods of 2 h and 84 days, respectively.

year	journal	country	edition	language
2004-07-30	Arzneimittelforschung

https://doi.org/10.1055/s-0031-1296978

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