Selective Synthesis of New Fluorinated Alicyclic β-Amino Ester Stereoisomers

6533b82dfe1ef96bd12911a8

RESEARCH PRODUCT

Selective Synthesis of New Fluorinated Alicyclic β-Amino Ester Stereoisomers

Santos Fustero Enikő Forró Ferenc Fülöp Ferenc Fülöp Loránd Kiss

subject

chemistry.chemical_classification Stereochemistry Organic Chemistry Cyclohexene Regioselectivity Amino acid Hydroxylation chemistry.chemical_compound Alicyclic compound Enantiopure drug chemistry Organic chemistry Stereoselectivity Physical and Theoretical Chemistry Enantiomer

description

New fluorinated alicyclic β-amino ester stereoisomers with a cyclohexene or cyclohexane skeleton were prepared from cis- or trans-2-aminocyclohex-3-enecarboxylic acids in five or six steps through a regio- and stereoselective hydroxylation and hydroxy–fluorine exchange. Fluorinated aminoester enantiomers were synthesized from enantiopure cis- or trans-2-aminocyclohexenecarboxylic acid (prepared byenzymatic resolution of the racemic substances).

year	journal	country	edition	language
2011-06-29	European Journal of Organic Chemistry

https://doi.org/10.1002/ejoc.201100583

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