Diastereo- and enantioselective synthesis of orthogonally protected 2,4-diaminocyclopentanecarboxylates: a flip from beta-amino- to beta,gamma-diamin…

2007

Conformationally restricted, orthogonally protected 2,4-diaminocarboxylates with a cyclopentane skeleton were efficiently synthesized from beta-lactam 6, the syntheses involving strategies of diastereoselective epoxidation of the beta-lactam and the corresponding monoprotected amino esters with opposite selectivities followed by regioselective opening of the oxirane ring with sodium azide. The enantiomers were also prepared. This new class of compounds can be regarded not only as conformationally constrained beta,gamma-diamino acid derivatives but also as potential functionalized carbocyclic nucleoside precursors.

A Selective Synthesis of Fluorinated Cispentacin Derivatives

2014

A facile selective method has been developed for the synthesis of new fluorine-containing cispentacin stereoisomers. Mono- and difluorinated cispentacin derivatives were synthetized from a bicyclic β-lactam in five or six steps involving a regio- and stereoselective hydroxylation through iodooxazoline formation, followed by deoxygenation by fluorination. Starting from an enantiomerically pure bicyclic β-lactam obtained by enzymatic resolution of the racemic compound, an enantiodivergent procedure allowed the preparation of both dextro- and levorotatory difluorinated cispentacins.

A Stereocontrolled Protocol to Highly Functionalized Fluorinated Scaffolds through a Fluoride Opening of Oxiranes

2016

A novel selective and substrate-dependent synthetic protocol has been developed towards the synthesis of various fluorine-containing, highly functionalized cycloalkane derivatives. The method involves the stereoselective epoxidation of some unsaturated cyclic beta-amino acid derivatives as model compounds, followed by a regioselective fluoride opening of oxiranes under various conditions with Deoxofluor and XtalFluor-E reagents, thereby offering an insight into this new epoxide opening methodology with fluoride.

Chemoselective, Substrate-directed Fluorination of Functionalized Cyclopentane β-Amino Acids

2016

This work describes a substrate-directed fluorination of some highly functionalized cyclopentane derivatives. The cyclic products incorporating CH2 F or CHF2 moieties in their structure have been synthesized from diexo- or diendo-norbornene β-amino acids following a stereocontrolled strategy. The synthetic study was based on an oxidative transformation of the ring carbon-carbon double bond of the norbornene β-amino acids, followed by transformation of the resulted "all cis" and "trans" diformyl intermediates by fluorination with "chemodifferentiation".

Efficient regio- and stereoselective access to novel fluorinated ?-aminocyclohexanecarboxylates

2013

A regio- and stereoselective method has been developed for the synthesis of novel fluorinated 2-aminocyclohexanecarboxylic acid derivatives with the fluorine attached to position 4 of the ring. The synthesis starts from either cis- or trans-β-aminocyclohex-4-enecarboxylic acids and involves regio- and stereoselective transformation of the ring C–C double bond through iodooxazine formation and hydroxylation, followed by hydroxy–fluorine or oxo–fluorine exchange.

Synthesis of Highly Functionalized Fluorinated Cispentacin Derivatives

2012

Fluorinated highly functionalized cispentacin derivatives were synthetised starting from an unsaturated bicyclic b-lactam through C¼C bond functionalization via the dipolar cycloaddition of a nitrile oxide, isoxazoline opening, and fluorination by OH/F exchange.

Functionalized Dialdehydes as Promising Scaffolds for Access to Heterocycles and β-Amino Acids: Synthesis of Fluorinated Piperidine and Azepane Deriv…

2017

Functionalized dialdehydes are considered important substrates that can be transformed into various substituted heterocyclic, alicyclic, and polysubstituted compounds. Here, we report a robust stereocontrolled procedure for the synthesis of novel functionalized trifluoromethyl-containing piperidine and azepane derivatives, based on oxidative ring cleavage of the C=C bond of diversely substituted cycloalkenes, followed by reductive ring closure of the diformyl intermediates in the presence of fluorine-containing amines.

Asymmetric synthesis of α,β-diamino acid derivatives with an aziridine-, azetidine- and γ-lactone-skeleton via Mannich-type additions across α-chloro…

2012

The efficient asymmetric synthesis of new chiral γ-chloro-α,β-diamino acid derivatives via highly diastereoselective Mannich-type reactions of N-(diphenylmethylene) glycine esters across a chiral α-chloro-N-p-toluenesulfinylimine was developed. The influence of the base, LDA or LiHMDS, used for the formation of the glycine enolates, was of great importance for the anti-/syn-diastereoselectivity of the Mannich-type reaction. The γ-chloro-α,β-diamino acid derivatives proved to be excellent building blocks for ring closure towards optically pure anti- and syn-β,γ-aziridino-α-amino esters, and subsequent ring transformation into trans-3-aminoazetidine-2-carboxylic acid derivatives and α,β-diami…

Diversity-Oriented Synthesis of Highly Functionalized Alicycles across Dipolar Cycloaddition/Metathesis Reaction

2021

AbstractThis Account gives an insight into the selective functionalization of some readily available commercial cyclodienes across simple chemical transformations into functionalized small-molecular scaffolds. The syntheses involved selective cycloadditions, followed by ring-opening metathesis (ROM) of the resulting azetidin-2-one derivatives or isoxazoline frameworks and selective cross metathesis (CM) by discrimination of the C=C bonds on the alkenylated heterocycles. The CM protocols have been described when investigated under various conditions with the purpose on exploring chemodifferentiation of the olefin bonds and a study on the access of the corresponding functionalized β-lactam or…

An Insight into Substrate-Dependent Fluorination of some Highly Substituted Alicyclic Scaffolds

2017

The substrate-dependent fluorination of some highly-functionalized cyclopentane derivatives with multiple chiral centers has been investigated. The key steps of the stereocontrolled syntheses are the oxidative cleavage of the ring carbon–carbon double bond of readily available diexo or diendo norbornene β-amino acid derivatives followed by transformation of the resulted dialdehyde stereoisomers by reduction. Finally, substrate-directable chemodifferentiation of different types of hydroxy groups under fluorination procedures gave various densely functionalized alicyclic derivatives or heterocycles.

Novel functionalized cispentacin derivatives. Synthesis of 1,2,3-triazole-substituted 2-aminocyclopentanecarboxylate stereoisomers

2008

Four 1,2,3-triazole-substituted ethyl 2-amino-3-hydroxycyclopentanecarboxylate diastereomers (3,4-disubstituted cispentacins) with a cyclopentane skeleton were prepared in enantiomerically pure form from racemic β-lactam 7 via enzymatic ring opening, epoxidation and selective ring opening of the oxirane ring with sodium azide. The formation of the 1,2,3-triazole ring system involved click chemistry: 1,3-dipolar cycloaddition of the corresponding 4-substituted azidocarboxylates with diethyl acetylenedicarboxylate.

Fluorination of some highly functionalized cycloalkanes: chemoselectivity and substrate dependence.

2017

A study exploring the chemical behavior of some dihydroxylated β-amino ester stereo- and regioisomers, derived from unsaturated cyclic β-amino acids is described. The nucleophilic fluorinations involving hydroxy–fluorine exchange of some highly functionalized alicyclic diol derivatives have been carried out in view of selective fluorination, investigating substrate dependence, neighboring group assistance and chemodifferentiation.

Synthesis of novel fluorinated building blocks via halofluorination and related reactions.

2020

A study exploring halofluorination and fluoroselenation of some cyclic olefins, such as diesters, imides, and lactams with varied functionalization patterns and different structural architectures is described. The synthetic methodologies were based on electrophilic activation through halonium ions of the ring olefin bonds, followed by nucleophilic fluorination with Deoxo-Fluor®. The fluorine-containing products thus obtained were subjected to elimination reactions, yielding various fluorine-containing small-molecular entities.

Regio- and diastereoselective fluorination of alicyclic β-amino acids.

2011

A regio- and stereoselective approach to fluorinated β-aminocyclohexene or cyclohexane esters has been developed, starting from a bicyclic β-lactam (1). The procedure involves six or seven steps, based on regio- and stereoselective iodolactonization, lactone opening and hydroxy–fluorine exchange. The method has been extended to the synthesis of fluorinated amino ester enantiomers.

Asymmetric synthesis of chloroisothreonine derivatives via syn-stereoselective Mannich-type additions across N-sulfinyl-α- chloroimines

2014

Mannich-type reactions of O-Boc glycolic esters across chiral N-sulfinyl-α-chloroaldimines resulted in the efficient and syn-stereoselective synthesis of new γ-chloro-α-hydroxy-β-amino esters (dr > 99:1). The α-coordinating ability of the chlorine atom was of great importance for the diastereoselectivity of the Mannich-type reaction and overruled the chelation of the sulfinyl oxygen with the lithium ion of the incoming E-enolate in the transition state model. These novel chloroisothreonine derivatives proved to be excellent building blocks in asymmetric synthesis of novel syn-β,γ-aziridino-α-hydroxy esters and biologically relevant trans-oxazolidinone carboxylic esters.

Selective Synthesis of New Fluorinated Alicyclic β-Amino Ester Stereoisomers (Eur. J. Org. Chem. 26/2011)

2011

The cover picture shows a waterfall located in the Eastern Carpathians in Transylvania, near Bicaz Canyon. Although fluorinated organic compounds are nonexistent in nature, an increasing number of drugs (25 %) on the market contain at least one fluorine atom. Cyclic fluorinated β-amino acid derivatives have been synthesized by selective hydroxylation and hydroxy?fluorine exchange. Details are discussed in the article by F. Fulop et al. on p. 4993 ff.

Back Cover: Chemoselective, Substrate-directed Fluorination of Functionalized Cyclopentane β-Amino Acids (Chem. Asian J. 23/2016)

2016

Chemodiscrimination of Olefin Bonds Through Cross‐Metathesis Reactions – Synthesis of Functionalized β‐Lactam and β‐Amino Acid Derivatives

2019

Fluorine-containing drugs approved by the FDA in 2019

2020

Abstract Eleven new fluorine-containing FDA-approved drugs have been profiled and details of their discovery and preparation are discussed. Therapeutic areas include schizophrenia, migraine, multiple sclerosis, insomnia, rheumatoid arthritis, anti-tuberculosis, breast cancer, lymphoma kinase inhibitor, serotonin receptor antagonist. New pharmaceuticals feature four examples of aromatic fluorine, three aromatic CF3 group, three aliphatic CF3 and one compound with aromatic CF3O group. Furthermore, among the new compounds, six are chiral and seven are derived from tailor-made amino acids.

Synthesis of highly functionalized β-aminocyclopentanecarboxylate stereoisomers by reductive ring opening reaction of isoxazolines

2012

A rapid and simple procedure was devised for the synthesis of multifunctionalized cyclic β-amino esters and γ-amino alcohols via the 1,3-dipolar cycloaddition of nitrile oxides to β-aminocyclopentenecarboxylates. The opening of the isoxazoline reductive ring to the corresponding highly functionalized 2-aminocyclopentanecarboxylates occurred stereoselectively with good yields.

Selective Synthesis of New Fluorinated Alicyclic β-Amino Ester Stereoisomers

2011

New fluorinated alicyclic β-amino ester stereoisomers with a cyclohexene or cyclohexane skeleton were prepared from cis- or trans-2-aminocyclohex-3-enecarboxylic acids in five or six steps through a regio- and stereoselective hydroxylation and hydroxy–fluorine exchange. Fluorinated aminoester enantiomers were synthesized from enantiopure cis- or trans-2-aminocyclohexenecarboxylic acid (prepared byenzymatic resolution of the racemic substances).

Fluorine-Containing Functionalized Cyclopentene Scaffolds Through Ring Contraction and Deoxofluorination of Various Substituted Cyclohexenes

2018

An insight into the synthesis of novel aryl-substituted alicyclic β-amino acid derivatives through substrate-directed palladium-catalysed regio- and …

2015

Novel aryl-substituted alicyclic β-amino acid derivatives were synthesized through substrate-determined palladium-catalysed cross-coupling of aryl iodides with five- or six-membered cycloalkene β-amino esters. The arylations were investigated with different catalysts, solvents, bases and aryl halides, and with some cyclohexene 2-aminocarboxylate isomers. The stereochemistry and the position of the ring olefinic bond of the starting 2-aminocycloalkanecarboxylate influenced the coupling reaction, and predetermined the structure of the arylated product.

Selective Transformation of Norbornadiene into Functionalized Azaheterocycles and β‐Amino Esters with Stereo‐ and Regiocontrol

2021

Novel functionalized azaheterocycles with multiple chiral centers have been accessed from readily available norbornene β-amino acids or β-lactams across a stereocontrolled synthetic route, based on ring-opening metathesis (ROM) of the staring unsaturated bicyclic amino esters, followed by selective cyclization through ring-closing metathesis (RCM). The RCM transformations have been studied under various experimental conditions to assess the scope of conversion, catalyst, yield, and substrate influence. The structure of the starting norbornene β-amino acids predetermined the structure of the new azaheterocycles, and the developed synthetic route took place with the conservation of the config…

Synthesis of Highly Functionalized Cyclopentanes as Precursors of Hydroxylated Azidocarbonucleosides

2009

Regio- and stereoisomers of functionalized azido amino alcohols with a cyclopentane skeleton were synthesized in enantiomerically pure forms. Enzymatic ring cleavage of racemic 2-azabicyclo[2.2.1]hept-5-en-3-one gave the corresponding amino acid and one enantiomer of the lactam stereospecifically. These were protected by esterification and carbamoylation, and then epoxidized. The resulting oxiranes underwent cleavage by sodium azide with complementary stereoselectivities. The regioisomeric products were easily separated by crystallization or column chromatography.

An Easy Stereoselective Access to β,γ-Aziridino α-Amino Ester Derivatives via Mannich Reaction of Benzophenone Imines of Glycine Esters with N-Sulfon…

2007

Mannich-type addition of benzophenone imine glycinates across newly synthesized N-(p-toluenesulfonyl) alpha-chloroaldimines afforded gamma-chloro-alpha,beta-diamino ester derivatives with moderate diastereoselectivity as separable mixtures of anti and syn diastereomers. The gamma-chloro-alpha,beta-diamino esters were efficiently cyclized under basic conditions to the corresponding beta,gamma-aziridino alpha-amino ester derivatives, representing a new class of conformationally constrained heterocyclic alpha,beta-diamino acid derivatives. The relative configuration of the aziridines was determined via X-ray diffraction analysis. Mechanisms and intermediate transition states to explain the ste…

Synthesis of conformationally restricted 1,2,3-triazole-substituted ethyl β- and γ-aminocyclopentanecarboxylate stereoisomers. Multifunctionalized al…

2010

Abstract Stereoisomers of 1,2,3-triazole-functionalized, conformationally restricted β- or γ-amino esters with a cyclopentane skeleton were efficiently synthetized from the bicyclic β-lactam 6-azabicyclo[3.2.0]hept-3-en-7-one (1) and Vince γ-lactam (15) in five or six steps involving the azide–alkyne 1,3-dipolar cycloaddition of azido-substituted amino ester stereoisomers with nonsymmetric acetylenes. The azide–alkyne click reactions were investigated under thermal and Cu(I)-catalyzed conditions. Surprisingly, the thermally induced cycloaddition furnished the corresponding 1,4-triazoles regioselectively, which also took place selectively in response to Cu(I) catalysis.

Olefin-Bond Chemodifferentiation through Cross-Metathesis Reactions: A Stereocontrolled Approach to Functionalized β2,3 -Amino Acid Derivatives

2017

Diversity-Oriented Stereocontrolled Synthesis of Some Piperidine- and Azepane-Based Fluorine-Containing β-Amino Acid Derivatives

2020

AbstractStructural diversity-oriented synthesis of some azaheterocyclic β-amino acid derivatives has been accomplished by selective functionalization of readily available cyclodienes. The stereocontrolled synthetic concept was based on the oxidative ring cleavage of unsaturated cyclic β-amino acids derived from cycloalkadiene, followed by ring closing with double reductive amination, which furnished some conformationally restricted β-amino acid derivatives with a piperidine or azepane core.

Stereocontrolled Synthesis of Fluorine-Containing Piperidine γ-Amino Acid Derivatives

2018

Front Cover: Stereocontrolled Synthesis of Fluorine-Containing Piperidine γ-Amino Acid Derivatives (Eur. J. Org. Chem. 12/2019)

2019

Synthesis of novel functionalized cispentacins through C–C oxidative cleavage of diendo-norbornene β-amino acid

2013

Difunctionalized cispentacin derivatives with two new stereogenic centres have been synthesized from a diendo-norbornene β-amino acid in a stereocontrolled route, involving C–C double bond functionalization by dihydroxylation, followed by oxidative ring cleavage and transformation of the dialdehyde intermediates through a Wittig reaction.

Synthesis of novel isoxazoline-fused cispentacin stereoisomers

2009

Abstract New isoxazoline-fused cispentacins were prepared by the 1,3-dipolar cycloaddition of nitrile oxides to β-amino esters containing a cyclopentene skeleton. This synthetic procedure gave regio- and diastereoisomers of the cispentacins. The synthetic route was extended to the synthesis of these compounds in enantiomerically pure form.

Synthesis of fluorinated piperidine and azepane β-amino acid derivatives

2016

Abstract A convenient and robust stereocontrolled procedure has been developed for the synthesis of novel trifluoromethyl-containing piperidine and azepane β-amino ester stereoisomers. The synthesis started from readily available unsaturated bicyclic β-lactams and was based on oxidative cleavage of the ring C C double bond followed by ring closure of the diformyl intermediates in the presence of 2,2,2-trifluoroethylamine hydrochloride through reductive amination. The synthetic procedure has efficiently been extended towards the synthesis of mono- and difluorinated analogs.

Selective nitrile oxide dipolar cycloaddition for the synthesis of highly functionalized β-aminocyclohexanecarboxylate stereoisomers

2012

Highly functionalized β-aminocyclohexanecarboxylate regio- and stereoisomers were synthesized from a bicyclic β-lactam by successive regioselective iodolactonization, stereo- and regioselective nitrile oxide cycloaddition, lactone ring-opening and isoxazoline ring-opening.

A novel and selective fluoride opening of aziridines by XtalFluor-E. synthesis of fluorinated diamino acid derivatives.

2015

The selective introduction of fluorine onto the skeleton of an aminocyclopentane or cyclohexane carboxylate has been developed through a novel and efficient fluoride opening of an activated aziridine ring with XtalFluor-E. The reaction proceeded through a stereoselective aziridination of the olefinic bond of a bicyclic lactam and regioselective aziridine ring opening with difluorosulfiliminium tetrafluoroborate with the neighboring group assistance of the sulfonamide moiety to yield fluorinated diamino acid derivatives. The method based on the selective aziridine opening by fluoride has been generalized to afford access to mono- or bicyclic fluorinated substances.

Synthesis of fluorinated amino acid derivatives through late-stage deoxyfluorinations

2018

Abstract Fluorine chemistry has represented a hot topic in drug research over the last decade. Because of their pharmaceutical potential, fluorine-containing amino acids and related derivatives have acquired high importance among medicinal chemists. Therefore their synthesis and the development of various synthetic methods for these types of molecular scaffolds have gained increasing interest in synthetic organic chemistry. The current review focuses on synthetic protocols towards fluorine-containing amino acid derivatives through late-stage fluorination with various nucleophilic reagents, describing the access of various open-chain and cyclic α-, β-, γ-amino acid derivatives.

Synthesis of densely functionalized cispentacin derivatives through selective aziridination and aziridine opening reactions: Orthogonally protected d…

2014

A novel substrate-directed synthetic route to a series of highly functionalized, orthogonally protected di- or triaminocyclopentanecarboxylate derivatives with multiple chiral centres from an unsaturated bicyclic β-lactam has been accomplished by applying stereoselective ring C–C double bond aziridination with chloramine-T and phenyltrimethylammonium tribromide, followed by regioselective aziridine opening with different N,O nucleophiles and hydrides. The functionalization strategy was successfully extended for access to enantiomerically pure orthogonally protected triaminocarboxylates.

Substrate-dependent fluorinations of highly functionalized cycloalkanes

2016

Abstract Substrate-dependent fluorinations of several highly functionalized cycloalkanes with multiple stereocentres were investigated. The synthetic transformations were based on selective functionalization of the ring C C bonds of the readily available bicyclic β-lactams by epoxidation and regioselective nucleophilic oxirane opening with azide or cyanide, followed by hydroxy–fluorine exchange with Deoxofluor. Depending on the substituents and their relative steric arrangement, the attempted fluorinations produced different types of substituted cycloalkanes. These selective, substrate-directed synthetic procedures and their presumed pathways towards interesting highly functionalized fluori…

Chemical Aspects of Human and Environmental Overload with Fluorine

2021

Over the last 100-120 years, due to the ever-increasing importance of fluorine-containing compounds in modern technology and daily life, the explosive development of the fluorochemical industry led to an enormous increase of emission of fluoride ions into the biosphere. This made it more and more important to understand the biological activities, metabolism, degradation, and possible environmental hazards of such substances. This comprehensive and critical review focuses on the effects of fluoride ions and organofluorine compounds (mainly pharmaceuticals and agrochemicals) on human health and the environment. To give a better overview, various connected topics are also discussed: reasons an…

Asymmetric Methods for Carbon‐Fluorine Bond Formation

2021

Ring-opening metathesis of some strained bicyclic systems; stereocontrolled access to diolefinated saturated heterocycles with multiple stereogenic c…

2018

Ring-opening metathesis (ROM) of various unsaturated, constrained bicyclic ring systems has been investigated with the use of commercial ruthenium-based catalysts. Starting from various cyclodienes, the corresponding derived bicyclic lactone, lactam, and isoxazoline derivatives were submitted to ROM under ethenolysis. These functionalized, strained bicyclic systems afforded novel highly-functionalized diolefinated heterocyclic scaffolds in ROM reactions with stereocontrol, through the conservation of the configuration of the stereogenic centers of the starting compounds.

CCDC 919638: Experimental Crystal Structure Determination

2013

Related Article: Maria Cherepanova, Loránd Kiss, Reijo Sillanpää, Ferenc Fülöp|2013|RSC Advances|3|9757|doi:10.1039/C3RA41963K

CCDC 1495998: Experimental Crystal Structure Determination

2017

Related Article: Loránd Kiss, Melinda Nonn, Reijo Sillanpää, Matti Haukka, Santos Fustero, Ferenc Fülöp|2016|Chem.Asian J.|11|3376|doi:10.1002/asia.201601046

CCDC 977961: Experimental Crystal Structure Determination

2014

Related Article: Gert Callebaut, Filip Colpaert, Melinda Nonn, Loránd Kiss, Reijo Sillanpää, Karl W. Törnroos, Ferenc Fülöp, Norbert De Kimpe, Sven Mangelinckx|2014|Org.Biomol.Chem.|12|3393|doi:10.1039/C4OB00243A

CCDC 1562225: Experimental Crystal Structure Determination

2018

Related Article: Attila Márió Remete, Melinda Nonn, Santos Fustero, Matti Haukka, Ferenc Fülöp, Loránd Kiss|2017|Beilstein J.Org.Chem.|13|2364|doi:10.3762/bjoc.13.233

CCDC 1814087: Experimental Crystal Structure Determination

2018

Related Article: Attila Márió Remete, Melinda Nonn, Santos Fustero, Matti Haukka, Ferenc Fülöp, Loránd Kiss|2018|Eur.J.Org.Chem.|2018|3735|doi:10.1002/ejoc.201800057

CCDC 1057565: Experimental Crystal Structure Determination

2015

Related Article: Melinda Nonn, Loránd Kiss, Matti Haukka, Santos Fustero, Ferenc Fülöp|2015|Org.Lett.|17|1074|doi:10.1021/acs.orglett.5b00182

CCDC 2011188: Experimental Crystal Structure Determination

2021

Related Article: Attila Márió Remete, Tamás T Novák, Melinda Nonn, Matti Haukka, Ferenc Fülöp, Loránd Kiss|2020|Beilstein J.Org.Chem.|16|2562|doi:10.3762/bjoc.16.208

CCDC 1401005: Experimental Crystal Structure Determination

2015

Related Article: Loránd Kiss, Attila Márió Remete, Melinda Nonn, Santos Fustero, Reijo Sillanpää, Ferenc Fülöp|2016|Tetrahedron|72|781|doi:10.1016/j.tet.2015.12.017

CCDC 1038709: Experimental Crystal Structure Determination

2015

Related Article: Melinda Nonn, Loránd Kiss, Mikko M. Hänninen, Ferenc Fülöp|2015|RSC Advances|5|13628|doi:10.1039/C4RA16196C

CCDC 977962: Experimental Crystal Structure Determination

2014

Related Article: Gert Callebaut, Filip Colpaert, Melinda Nonn, Loránd Kiss, Reijo Sillanpää, Karl W. Törnroos, Ferenc Fülöp, Norbert De Kimpe, Sven Mangelinckx|2014|Org.Biomol.Chem.|12|3393|doi:10.1039/C4OB00243A

CCDC 2011187: Experimental Crystal Structure Determination

2021

Related Article: Attila Márió Remete, Tamás T Novák, Melinda Nonn, Matti Haukka, Ferenc Fülöp, Loránd Kiss|2020|Beilstein J.Org.Chem.|16|2562|doi:10.3762/bjoc.16.208

CCDC 1495999: Experimental Crystal Structure Determination

2017

Related Article: Loránd Kiss, Melinda Nonn, Reijo Sillanpää, Matti Haukka, Santos Fustero, Ferenc Fülöp|2016|Chem.Asian J.|11|3376|doi:10.1002/asia.201601046

CCDC 2011186: Experimental Crystal Structure Determination

2021

Related Article: Attila Márió Remete, Tamás T Novák, Melinda Nonn, Matti Haukka, Ferenc Fülöp, Loránd Kiss|2020|Beilstein J.Org.Chem.|16|2562|doi:10.3762/bjoc.16.208

CCDC 982910: Experimental Crystal Structure Determination

2014

Related Article: Loránd Kiss, Melinda Nonn, Enikő Forró, Reijo Sillanpää, Santos Fustero, Ferenc Fülöp|2014|Eur.J.Org.Chem.|2014|4070|doi:10.1002/ejoc.201402121

CCDC 977960: Experimental Crystal Structure Determination

2014

Related Article: Gert Callebaut, Filip Colpaert, Melinda Nonn, Loránd Kiss, Reijo Sillanpää, Karl W. Törnroos, Ferenc Fülöp, Norbert De Kimpe, Sven Mangelinckx|2014|Org.Biomol.Chem.|12|3393|doi:10.1039/C4OB00243A

CCDC 1814088: Experimental Crystal Structure Determination

2018

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CCDC 982909: Experimental Crystal Structure Determination

2014

Related Article: Loránd Kiss, Melinda Nonn, Enikő Forró, Reijo Sillanpää, Santos Fustero, Ferenc Fülöp|2014|Eur.J.Org.Chem.|2014|4070|doi:10.1002/ejoc.201402121

CCDC 1008231: Experimental Crystal Structure Determination

2015

Related Article: Melinda Nonn, Loránd Kiss, Enikő Forró, Reijo Sillanpää, Ferenc Fülöp|2014|Tetrahedron|70|8511|doi:10.1016/j.tet.2014.09.071

CCDC 1057564: Experimental Crystal Structure Determination

2015

Related Article: Melinda Nonn, Loránd Kiss, Matti Haukka, Santos Fustero, Ferenc Fülöp|2015|Org.Lett.|17|1074|doi:10.1021/acs.orglett.5b00182