Synthesis of Highly Functionalized Fluorinated Cispentacin Derivatives

6533b7d8fe1ef96bd126b6dc

RESEARCH PRODUCT

Synthesis of Highly Functionalized Fluorinated Cispentacin Derivatives

Melinda Nonn Melinda Nonn Reijo Sillanpää Mikko M. Hänninen Loránd Kiss Ferenc Fülöp Ferenc Fülöp

subject

Halogenation Bicyclic molecule Nitrile Oxide Oxides Bioengineering Cispentacin General Chemistry General Medicine beta-Lactams Biochemistry Cycloaddition chemistry.chemical_compound chemistry Cyclization Nitriles Molecular Medicine Surface modification Organic chemistry Cycloleucine ta116 Molecular Biology

description

Fluorinated highly functionalized cispentacin derivatives were synthetised starting from an unsaturated bicyclic b-lactam through C¼C bond functionalization via the dipolar cycloaddition of a nitrile oxide, isoxazoline opening, and fluorination by OH/F exchange.

year	journal	country	edition	language
2012-11-01	Chemistry & Biodiversity

https://doi.org/10.1002/cbdv.201200323

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