6533b827fe1ef96bd128669f
RESEARCH PRODUCT
Regio- and diastereoselective fluorination of alicyclic β-amino acids.
Loránd KissFerenc FülöpFerenc FülöpSantos FusteroEnikő Forrósubject
chemistry.chemical_classificationModels MolecularCyclohexaneBicyclic moleculeStereochemistryOrganic ChemistryIodolactonizationMolecular ConformationStereoisomerismCrystallography X-RayBiochemistryAmino acidchemistry.chemical_compoundAlicyclic compoundchemistryOrganic chemistryStereoselectivityPhysical and Theoretical ChemistryEnantiomerAmino AcidsLactonedescription
A regio- and stereoselective approach to fluorinated β-aminocyclohexene or cyclohexane esters has been developed, starting from a bicyclic β-lactam (1). The procedure involves six or seven steps, based on regio- and stereoselective iodolactonization, lactone opening and hydroxy–fluorine exchange. The method has been extended to the synthesis of fluorinated amino ester enantiomers.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2011-07-21 | Organicbiomolecular chemistry |