6533b85ffe1ef96bd12c2514
RESEARCH PRODUCT
Synthesis of novel isoxazoline-fused cispentacin stereoisomers
Loránd KissReijo SillanpääMelinda NonnFerenc FülöpFerenc FülöpEnikő Forrósubject
chemistry.chemical_classificationNitrileBicyclic moleculeStereochemistryOrganic ChemistryDiastereomerCispentacinBiochemistryCycloadditionAmino acidchemistry.chemical_compoundchemistryDrug DiscoveryOrganic chemistryCyclopentenedescription
Abstract New isoxazoline-fused cispentacins were prepared by the 1,3-dipolar cycloaddition of nitrile oxides to β-amino esters containing a cyclopentene skeleton. This synthetic procedure gave regio- and diastereoisomers of the cispentacins. The synthetic route was extended to the synthesis of these compounds in enantiomerically pure form.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-05-01 | Tetrahedron Letters |