6533b854fe1ef96bd12afc91
RESEARCH PRODUCT
Diversity-Oriented Stereocontrolled Synthesis of Some Piperidine- and Azepane-Based Fluorine-Containing β-Amino Acid Derivatives
Matti HaukkaEnikő ForróDominika KaraLoránd KissMelinda NonnMelinda NonnLamiaa Ouchakoursubject
chemistry.chemical_classification010405 organic chemistryStereochemistryOrganic ChemistryFluorine containing010402 general chemistryCleavage (embryo)Ring (chemistry)01 natural sciencesReductive aminationCatalysis0104 chemical sciencesAmino acidchemistry.chemical_compoundchemistryAzepanePiperidineSelectivitydescription
AbstractStructural diversity-oriented synthesis of some azaheterocyclic β-amino acid derivatives has been accomplished by selective functionalization of readily available cyclodienes. The stereocontrolled synthetic concept was based on the oxidative ring cleavage of unsaturated cyclic β-amino acids derived from cycloalkadiene, followed by ring closing with double reductive amination, which furnished some conformationally restricted β-amino acid derivatives with a piperidine or azepane core.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-12-14 | Synthesis |