6533b82cfe1ef96bd129009d
RESEARCH PRODUCT
Fluorine-containing drugs approved by the FDA in 2019
Vadim A. SoloshonokVadim A. SoloshonokHiroki MoriwakiJianlin HanSantos FusteroLoránd KissAttila Márió RemeteHaibo MeiYupiao Zousubject
chemistry.chemical_classificationKinasebusiness.industry03.01. Általános orvostudományFluorine containing02 engineering and technologyGeneral ChemistryPharmacology010402 general chemistry021001 nanoscience & nanotechnologymedicine.disease01 natural sciences0104 chemical sciencesAmino acidBreast cancerchemistryMigraineRheumatoid arthritismedicineSerotonin receptor antagonist0210 nano-technologybusinessdescription
Abstract Eleven new fluorine-containing FDA-approved drugs have been profiled and details of their discovery and preparation are discussed. Therapeutic areas include schizophrenia, migraine, multiple sclerosis, insomnia, rheumatoid arthritis, anti-tuberculosis, breast cancer, lymphoma kinase inhibitor, serotonin receptor antagonist. New pharmaceuticals feature four examples of aromatic fluorine, three aromatic CF3 group, three aliphatic CF3 and one compound with aromatic CF3O group. Furthermore, among the new compounds, six are chiral and seven are derived from tailor-made amino acids.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-09-01 | Chinese Chemical Letters |