6533b834fe1ef96bd129ce92
RESEARCH PRODUCT
An insight into the synthesis of novel aryl-substituted alicyclic β-amino acid derivatives through substrate-directed palladium-catalysed regio- and stereoselective cross-coupling
Loránd KissMikko M. HänninenFerenc FülöpFerenc FülöpMelinda NonnMelinda Nonnsubject
chemistry.chemical_classificationsynthesisGeneral Chemical EngineeringArylCyclohexenechemistry.chemical_elementGeneral ChemistryRing (chemistry)Medicinal chemistryCoupling reactionCatalysischemistry.chemical_compoundAlicyclic compoundchemistrycross-couplingOrganic chemistryta116CycloalkenePalladiumdescription
Novel aryl-substituted alicyclic β-amino acid derivatives were synthesized through substrate-determined palladium-catalysed cross-coupling of aryl iodides with five- or six-membered cycloalkene β-amino esters. The arylations were investigated with different catalysts, solvents, bases and aryl halides, and with some cyclohexene 2-aminocarboxylate isomers. The stereochemistry and the position of the ring olefinic bond of the starting 2-aminocycloalkanecarboxylate influenced the coupling reaction, and predetermined the structure of the arylated product.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-01-01 | RSC Advances |