6533b7cefe1ef96bd12571d3
RESEARCH PRODUCT
Diastereo- and enantioselective synthesis of orthogonally protected 2,4-diaminocyclopentanecarboxylates: a flip from beta-amino- to beta,gamma-diaminocarboxylates.
Eniko ForroReijo SillanpääLoránd KissFerenc Fülöpsubject
Ethylene OxideAmino estersChemistryStereochemistryOrganic ChemistryEnantioselective synthesisCarboxylic AcidsMolecular ConformationEpoxideRegioselectivityEstersStereoisomerismCyclopentanesbeta-LactamsChemical synthesischemistry.chemical_compoundDiamineLactamSodium azideSodium Azidedescription
Conformationally restricted, orthogonally protected 2,4-diaminocarboxylates with a cyclopentane skeleton were efficiently synthesized from beta-lactam 6, the syntheses involving strategies of diastereoselective epoxidation of the beta-lactam and the corresponding monoprotected amino esters with opposite selectivities followed by regioselective opening of the oxirane ring with sodium azide. The enantiomers were also prepared. This new class of compounds can be regarded not only as conformationally constrained beta,gamma-diamino acid derivatives but also as potential functionalized carbocyclic nucleoside precursors.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2007-10-16 | The Journal of organic chemistry |