6533b82dfe1ef96bd1291205

RESEARCH PRODUCT

Gd-DTPA in blood-ocular barrier damage: a new diagnostic tool for future application in MRI?

Adelfio Elio CardinaleL. ManfrèA. MangiameliF. PonteG. CardellaRoberto LagallaGiuseppe Giuffrè

subject

Retinamedicine.anatomical_structuremedicine.diagnostic_testbusiness.industrySurface coilMedicineFuture applicationMagnetic resonance imagingsense organsNuclear medicinebusinessBlood–ocular barrier

description

The blood-brain barrier is not the only neuroepithelial blood filter in the body: the eye too is supported by a highly specialised microvascular filter, the so-called blood-ocular barrier (BOB). The BOB is actually divided into a blood-aqueous (BAB) and a blood-retinal (BRB) barrier, filtering the aqueous fluid and biological supplies, respectively, to the retina. The authors’ purpose was to study the possibility of imaging BAB or BRB damage by contrast-enhanced MRI: they examined 21 patients with a 0.5 T system and surface coil. Despite the normal findings in the damaged eyes immediately after a Gd-DTPA bolus, delayed contrast-enhanced MRI was able to show focal or diffuse barrier damage.

yearjournalcountryeditionlanguage
1995-01-01
https://doi.org/10.1007/978-3-642-79434-6_180