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RESEARCH PRODUCT
Clinical significance of abdominal lymphadenopathy in chronic liver disease
J M RodrigoJuan-angel Del OlmoM A SerraA. EscuderoF RodríguezJosé-manuel EstebanLuis Maldonadosubject
Malemedicine.medical_specialtyPathologyCirrhosisAcoustics and UltrasonicsHepatitis C virusBiophysicsAntineoplastic Agentsmedicine.disease_causeChronic liver diseaseGastroenterologyLiver diseaseInternal medicineAbdomenmedicineHumansRadiology Nuclear Medicine and imagingProspective StudiesLymphatic DiseasesUltrasonographyHepatitis B virusHepatitisAnalysis of VarianceRadiological and Ultrasound Technologymedicine.diagnostic_testbusiness.industryLiver DiseasesInterferon-alphaMiddle Agedmedicine.diseasemedicine.anatomical_structureLiverLiver biopsyChronic DiseaseAbdomenFemaleLymph Nodesbusinessdescription
Abstract The possibility of assessing the relationship of ultrasound (US)-detected abdominal lymphadenopathy with etiology, biochemical findings, and histologic data in patients with chronic liver disease was evaluated. US examination of the upper abdomen was performed in 321 consecutive patients with various chronic liver disorders and 56 control patients. The prevalence of lymphadenopathy in chronic liver disease was 38%. This prevalence varied according to etiology of liver disease, from 50% in chronic hepatitis C virus (HCV) to less than 10% in alcoholicc cirrhosis and hepatitis B-virus (HBV)-related chronic liver disease. Patients with lymphadenopathy showed significantly higher serum levels of AST and ALT, as well as greater histopathological severity on liver biopsy specimens. In anti-HCV positive patients, there were no differences in the prevalence of lymphadenopathy according to HCV genotypes, whereas lymphadenopathy occurred less frequently in responders to interferon therapy than in nonresponders. (E-mail: delolmo_jua@gva.es)
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2002-04-30 | Ultrasound in Medicine & Biology |