6533b82dfe1ef96bd129140e
RESEARCH PRODUCT
Application of whole genome amplification for forensic analysis
Angel CarracedoNiels MorlingC.r. ThackerClaus BørstingDenise Syndercombe-courtPeter M. SchneiderM.k. BaloghP. Sánchez Dizsubject
GeneticsWhole Genome AmplificationForensic sciencechemistry.chemical_compoundgenomic DNAchemistryDna concentrationMultiple displacement amplificationLocus (genetics)General MedicineBiologyPcr analysisDNAdescription
Abstract Fundamental to most forensic analyses is the availability of genomic DNA of adequate quality and quantity. To perform a multitude of genetic analyses and assays requires a sufficiently large amount of template. However, DNA yield from forensic samples is frequently limiting the extent of genetic typing. A possible solution to overcome this “bottleneck” of forensic and paleoarcheological DNA analyses could be the amplification of the entire genomic DNA prior to locus specific PCR analysis. Whole Genome Amplification appears to be a promising tool to obtain sufficient DNA amounts from forensic samples of limited quantity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2006-04-01 |