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RESEARCH PRODUCT

Retention mechanisms for ER and Golgi membrane proteins

Liwen JiangByung-ho KangFernando AnientoYi CaiCaiji GaoYejun WangDavid G. Robinson

subject

Golgi membraneSecretory PathwayKKXXMolecular Sequence DataGolgi ApparatusMembrane ProteinsGolgi TargetingPlant ScienceCOPIGolgi apparatusBiologyEndoplasmic ReticulumCoat Protein Complex ICell biologysymbols.namesakeMembrane proteinPlant CellssymbolsAmino Acid SequenceIntegral membrane proteinSecretory pathway

description

Unless there are mechanisms to selectively retain membrane proteins in the endoplasmic reticulum (ER) or in the Golgi apparatus, they automatically proceed downstream to the plasma or vacuole membranes. Two types of coat protein complex I (COPI)-interacting motifs in the cytosolic tails of membrane proteins seem to facilitate membrane retention in the early secretory pathway of plants: a dilysine (KKXX) motif (which is typical of p24 proteins) for the ER and a KXE/D motif (which occurs in the Arabidopsis endomembrane protein EMP12) for the Golgi apparatus. The KXE/D motif is highly conserved in all eukaryotic EMPs and is additionally present in hundreds of other proteins of unknown subcellular localization and function. This novel signal may represent a new general mechanism for Golgi targeting and the retention of polytopic integral membrane proteins.

yearjournalcountryeditionlanguage
2014-08-01Trends in Plant Science
https://doi.org/10.1016/j.tplants.2014.04.004