6533b82dfe1ef96bd1291574

RESEARCH PRODUCT

Evidence that steric factors modulate reactivity of tautomeric iron-oxo species in stereospecific alkane C-H hydroxylation

Mainak MitraMiquel CostasEbbe NordlanderMatti HaukkaJulio Lloret-fillol

subject

Steric effectsStereochemistryIronrautaHydroxylationOxidacióIron compoundsCatalysisCatalysisHydroxylationchemistry.chemical_compoundStereospecificityCatàlisiCoordination ComplexesAlkanesOxidationMaterials ChemistryReactivity (chemistry)Hydrogen peroxideta116Alkylchemistry.chemical_classificationMolecular StructurekoordinaatioyhdisteetMetals and AlloysStereoisomerismcoordination compundsFerro -- CompostosGeneral ChemistryHydrogen PeroxideTautomer3. Good healthSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialschemistryCeramics and CompositesOxygenases

description

A new iron complex mediates stereospecific hydroxylation of alkyl C-H bonds with hydrogen peroxide, exhibiting excellent efficiency. Isotope labelling studies provide evidence that the relative reactivity of tautomerically related oxo-iron species responsible for the C-H hydroxylation reaction is dominated by steric factors This work has been supported by the European Union (the Erasmus Mundus program), the International Research Training Group Metal Sites in Biomolecules: Structures, Regulation and Mechanisms (www.biometals.eu), and COST Action CM1003. M.C. acknowledges ERC-29910, MINECO of Spain for CTQ2012- 37420-C02-01/BQU and CSD2010-00065, catalan DIUE (2009SGR637) and an ICREA academia award. J.Ll. thanks MICINN for a RyC contract

yearjournalcountryeditionlanguage
2014-01-01
https://hdl.handle.net/2072/320881