6533b82dfe1ef96bd12915cb
RESEARCH PRODUCT
The influence of Ca2+ antagonists on the ciliary activity of the guinea pig trachea.
Jan MaurerW. J. MannHerbert Riechelmannsubject
medicine.medical_specialtyNifedipineGuinea PigsGuinea pigDiltiazemNifedipineInternal medicineMedicineAnimalsDiltiazemCiliaRespiratory systemVoltage-dependent calcium channelbusiness.industryCiliary activityGeneral MedicineRinger's SolutionTracheaEndocrinologymedicine.anatomical_structureOtorhinolaryngologyMucociliary ClearanceAnesthesiaRespiratory epitheliumCalciumIsotonic SolutionsbusinessRespiratory tractmedicine.drugdescription
The ciliary activity of the guinea pig tracheal respiratory epithelium was measured using a photoelectric device. Fourteen animals were administered 75 mg diltiazem/kg body weight 2 days, 1 day and 4 h prior to the investigation. Thirteen animals served as controls. In the pretreated group, the mean ciliary stroke frequency (13.4 +/- 3.0 Hz) was significantly lower (P = 0.02) than in the control group (16.6 +/- 3.7 Hz). The application of aerosolized 0.3 mmol/l nifedipine solution on the tracheal preparations of the control animals also significantly reduced the stroke frequency (P = 0.02). The ciliary activity never dropped beyond a frequency of about 8 Hz. The most probable interpretation of these results is a modulating effect of Ca2+ antagonists on ciliary activity by blocking voltage-gated calcium channels.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1990-01-01 | European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery |