6533b82dfe1ef96bd1291a36

RESEARCH PRODUCT

Burkitt's lymphoma of the jaws in the Amazon region of Brazil

Hélder-antônio Rebelo-pontesMichelle-carvalho De AbreuDouglas-magno GuimarãesFelipe Paiva FonsecaBruno Augusto Benevenuto De AndradeOslei Paes De AlmeidaDécio-dos-santos-pinto JúniorFlávia-sirotheau Corrêa-pontes

subject

immune system diseaseshemic and lymphatic diseasesUNESCO::CIENCIAS MÉDICASOdontología:CIENCIAS MÉDICAS [UNESCO]Ciencias de la salud

description

Objectives: To describe the clinicopathologic and immunohistochemical features of Burkitt's lymphoma of the jaws in 7 patients of Northern Brazil. Study Design: Clinical data concerning gender, age, affected site, clinical presentation, symptomatology and follow-up were collected from the clinical files. Histopathology was complemented with a broad immunohistochemical panel and in situ hybridization for Epstein-Barr virus (EBV). Results: Most of the patients were infants and 5 out of 7 were males. The mandible was affected in 5 cases and all patients also presented abdominal involvement. All cases were positive for CD45, CD20, CD79a, CD10, Bcl-6 and EBV. Ki-67 proliferative index was approximately 100%. Six patients were treated with R-CHOP (Rituximab + Cyclophosphamide, Doxorubicin, Vincristine and Prednisolone) chemotherapy, and 2 of these died of the disease. One young adult patient refused treatment and died 3 months after initial diagnosis. Conclusions: Burkitt's lymphoma of the jaws diagnosed in the Amazon region of Brazil present similar clinicopathologic features to those described in endemic areas of Africa, including EBV positivity.

yearjournalcountryeditionlanguage
2014-01-01
http://hdl.handle.net/10550/36855