6533b82dfe1ef96bd1291adb

RESEARCH PRODUCT

Incidences de l’ischémie cérébrale sur la fonction et la sensibilité cardiaques à l’ischémie

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description

For years, the relationship between cardiac and neurological ischemic events has been limited to overlapping pathophysiological mechanisms and common risk factors. However, acute stroke may induce dramatic changes in cardiovascular function.The aim of this study was to evaluate how prior cerebrovascular lesions affect myocardial function and signaling in vivo and ex vivo, and how they influence cardiac vulnerability to ischemia-reperfusion injury and the expression of cardiac genes and proteins involved in cardioprotective pathways.Thus, in our work, we studied cardiac function in a rat stroke model induced by cerebral embolization.The main results show that experimental stroke 1/ impaired cardiac function both in vivo and ex vivo, 2/ impaired myocardial recovery following ischemia, 3/ involved sympathetic nervous system, 4/ involved nitro-oxidative stress, 5/ impaired one of the cardioprotective pathways, 6/ involved GDF15 at cerebral and cardiac levels.Our findings indicate that stroke not only impairs cardiac contractility and also worsens myocardial vulnerability to ischemia. The underlying molecular mechanisms of stroke-induced myocardial alterations after cerebral embolization remain to be established insofar as they may involve the cytokine GDF-15.