Search results for "Avc"
showing 8 items of 8 documents
Intérêt du growth differentiation factor 15 (GDF15) comme biomarqueur pronostique après la survenue d'un Accident Vasculaire Cérébral ischémique (AVC)
2018
Introduction Le GDF15 est un biomarqueur de mauvais pronostic dans certaines pathologies cardiovasculaires comme le syndrome coronarien aigu. Son interet dans le domaine de AVC n’a ete que peu etudie a ce jour. Objectifs Notre travail consistait a l’evaluation des taux de GDF15 chez des patients hospitalises a la phase aigue d’un AVC ischemique traites par fibrinolyse et/ou thrombectomie. L’objectif principal etait d’evaluer l’association entre les taux de GDF15 et la recuperation fonctionnelle a 3 mois. Methodes Au total, 174 patients ont ete inclus entre le 16/01 et le 30/09/2017. Le consentement etait recueilli oralement. Des prelevements biologiques ont ete realises a l’admission du pat…
Impact of t-PA administration on brain BDNF levels in physiological conditions and in circulating BDNF levels in ischemic conditions : Human and anim…
2014
Our objective was to test the hypothesis that the beneficial effect of the administration of the recombinant form of tissue plasminogen activator (rt-PA) in ischemic stroke patient not only results from its fibrinolytic activity but also from its ability to increase brain-derived neurotrophic factor (BDNF) in the brain. To this end, we conducted an initial study to evaluate the effect of rt-PA on brain BDNF levels in healthy animals. In a second study, we investigated the effect of rt-PA on serum BDNF levels in ischemic stroke patients and in animals subjected to permanent focal cerebral ischemia. Blood samples were obtained from patient on admission (D0), D1, D7 and D90 after stroke and in…
Adapting hierarchical bidirectional inter prediction on a GPU-based platform for 2D and 3D H.264 video coding
2013
The H.264/AVC video coding standard introduces some improved tools in order to increase compression efficiency. Moreover, the multi-view extension of H.264/AVC, called H.264/MVC, adopts many of them. Among the new features, variable block-size motion estimation is one which contributes to high coding efficiency. Furthermore, it defines a different prediction structure that includes hierarchical bidirectional pictures, outperforming traditional Group of Pictures patterns in both scenarios: single-view and multi-view. However, these video coding techniques have high computational complexity. Several techniques have been proposed in the literature over the last few years which are aimed at acc…
Microglial and BDNF impact on the induction of the post ischemic neuroplasticity
2011
Evidences showing that under certain circumstances, inflammatory response could be neuroprotective and could also promote adult neurogenesis are growing. In this context, the objective of this work was to investigate the impact of microglial cells in the neuroplastic events. Rats were subjected to photothrombotic ischemia and microglial cells activation was blocked by the mean of poly(ADP-ribose)polymérase-1 (PARP-1) inhibition using 3- aminobenzamide (3-AB) since this protein has been shown to play a major role in this activation. Our results show that PARP-1 activity reduction was associated with a strong repression of the acute microglial activation. Beside, 3-AB treated animals exhibite…
L’accident vasculaire cérébral en France : patients hospitalisés pour AVC en 2014 et évolutions 2008-2014
2017
ntroduction – In France, stroke is the first cause of death in women, and the third in men. The age-standardized rates of patients hospitalized for stroke increased in patients younger than 65 years between 2002 and 2008. After the implementation of the “National Stroke Action Plan” (2010-2014), this study analyzed trends in the rates of patients hospitalized for stroke and of patients hospitalized in stroke units since 2008.Methods – Data came from the French national hospital discharge databases (PMSI-MCO, 2008-2014). For each patient, the first annual hospitalization for stroke was selected. Crude hospitalized patients and in-hospital mortality rates were calculated by stroke subtypes, a…
A block access unit for 2D memory access
2007
Many of the coding tools in the H.264/AVC video coding standard are based on 2D processing resulting in rowwise and column-wise memory accesses starting from arbitrary memory addresses. This paper discusses a low-cost hardware realization of these accesses on sub-word parallel processors. The proposed block access unit is placed between the processor and memory. It supports unaligned 2D block accesses according to several 2D access patterns. The 2D block accesses are pipelinable and they result in minimum number of memory accesses required to deliver the desired data.
Evaluation du dispositif TéléAVC en Bourgogne, volet 3 : étude des coûts et des recettes associés à la prise en charge des patients téléfibrinolysés …
2015
Rapport pour l’Agence régionale de Santé de Bourgogne.
Incidences de l’ischémie cérébrale sur la fonction et la sensibilité cardiaques à l’ischémie
2019
For years, the relationship between cardiac and neurological ischemic events has been limited to overlapping pathophysiological mechanisms and common risk factors. However, acute stroke may induce dramatic changes in cardiovascular function.The aim of this study was to evaluate how prior cerebrovascular lesions affect myocardial function and signaling in vivo and ex vivo, and how they influence cardiac vulnerability to ischemia-reperfusion injury and the expression of cardiac genes and proteins involved in cardioprotective pathways.Thus, in our work, we studied cardiac function in a rat stroke model induced by cerebral embolization.The main results show that experimental stroke 1/ impaired …